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Before revascularization, detectable levels of xanthine oxidase were found only in patients with critical ischaemia. Clamping during bypass surgery led to release of xanthine oxidase in claudicants, but this activity reduced after 60 min. There was no evidence of lipid peroxidation during this time. Xanthine oxidase activity in brachial vein blood was higher than in femoral vein blood in patients with critical ischaemia before revascularization.<\/jats:p>","DOI":"10.1002\/bjs.1800830624","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:14:31Z","timestamp":1172866471000},"page":"798-802","source":"Crossref","is-referenced-by-count":4,"title":["Xanthine oxidase in critically ischaemic and claudicant limbs: Profile of activity during early reperfusion"],"prefix":"10.1093","volume":"83","author":[{"given":"A L","family":"Trewick","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, University College London Hospitals , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"El-Hassan","sequence":"additional","affiliation":[{"name":"Vascular Unit, University College London Hospitals , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Round","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, University College London Hospitals , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Adiseshiah","sequence":"additional","affiliation":[{"name":"Vascular Unit, University College London Hospitals , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"2024092910110340000_bib1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/bjs.1800810504","article-title":"Ischaemia-reperfusion injury","volume":"81","author":"Grace","year":"1994","journal-title":"Br J Surg"},{"key":"2024092910110340000_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"312","author":"McCord","year":"1985","journal-title":"N Engl J Med"},{"key":"2024092910110340000_bib3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/bjs.1800810714","article-title":"Role of thromboxane A2 in muscle injury following ischaemia","volume":"81","author":"Homer-Vanniasinkam","year":"1994","journal-title":"Br J Surg"},{"key":"2024092910110340000_bib4","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/bjs.1800780607","article-title":"Pathophysiology of ischaemia-reperfusion injury: central role of the neutrophil","volume":"78","author":"Welbourn","year":"1991","journal-title":"Br J Surg"},{"key":"2024092910110340000_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/bjs.1800791214","article-title":"Effect of free radical scavenging on skeletal muscle blood flow during postischaemic reperfusion","volume":"79","author":"Hardy","year":"1992","journal-title":"Br J Surg"},{"key":"2024092910110340000_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0003-9861(76)90088-6","article-title":"The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD + -dependent form (type D) to an O2-dependent form (type O)","volume":"172","author":"Waud","year":"1976","journal-title":"Arch Biochem Biophys"},{"key":"2024092910110340000_bib7","first-page":"203","article-title":"Roles of histamine, complement and xanthine oxidase in thermal injury of skin","volume":"135","author":"Friedl","year":"1989","journal-title":"Am J Pathol"},{"key":"2024092910110340000_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0076-6879(55)02228-3","volume":"2","author":"Price","year":"1955","journal-title":"Methods Enzymol"},{"key":"2024092910110340000_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1172\/JCI112001","article-title":"Systemic complement activation, lung injury, and products of lipid peroxidation","volume":"76","author":"Ward","year":"1985","journal-title":"J Clin Invest"},{"key":"2024092910110340000_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/096721099500300305","article-title":"31P nuclear magnetic resonance spectroscopy of acutely ischaemic limbs: the extent of changes and progress after reconstructive surgery","volume":"3","author":"Brotzakis","year":"1995","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"2024092910110340000_bib11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/bjs.1800791013","article-title":"Reperfusion injury in skeletal muscle: a prospective study in patients with acute limb ischaemia and claudicants treated by revascularization","volume":"79","author":"Adiseshiah","year":"1992","journal-title":"Br J Surg"},{"key":"2024092910110340000_bib12","first-page":"169","article-title":"Xanthine oxidase: its role in the no-reflow phenomenon","volume":"111","author":"Punch","year":"1992","journal-title":"Surgery"},{"key":"2024092910110340000_bib13","first-page":"491","article-title":"Ischaemia-reperfusion in humans. 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