{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:19:05Z","timestamp":1790108345189,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50GM49222-0"],"award-info":[{"award-number":["P50GM49222-0"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GMO8315"],"award-info":[{"award-number":["T32GMO8315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet-activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1\u00b726(0\u00b719), 1\u00b733(0\u00b726), 1\u00b704(0\u00b714) and 0\u00b786(0\u00b713) nmol superoxide per min per 1\u00b73 \u00d7 106 neutrophils respectively (P&amp;lt;0\u00b705). Priming at 3 h after injury was inhibited by mean(s.e.m.) 63\u00b78(7\u00b70) per cent by the PAF antagonist, WEB 2170 (P&amp;lt;0\u00b701). Mean(s.e.m.) plasma IL-8 was raised at 6 and 12 h after injury to 785(183) and 836(175) pg\/ml (P&amp;lt;0\u00b701). At 12 h after injury the plasma IL-8 level correlated directly with the number of units of red blood cells transfused (r=0\u00b764, P&amp;lt;0\u00b701), and was significantly higher in the group of six patients who developed MOF (P&amp;lt;0\u00b705). These data suggest that after trauma the mediators PAF and IL-8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL-8 may also be an early biochemical marker predicting the onset of MOF.<\/jats:p>","DOI":"10.1002\/bjs.1800831027","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:07:40Z","timestamp":1172747260000},"page":"1407-1412","source":"Crossref","is-referenced-by-count":60,"title":["Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure"],"prefix":"10.1093","volume":"83","author":[{"given":"A J","family":"Botha","sequence":"first","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F A","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E E","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V M","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"Silliman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A W","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center , Denver, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"2024092815515803600_bib1","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1001\/jama.1992.03490240060037","article-title":"Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome)","volume":"268","author":"Bone","year":"1992","journal-title":"JAMA"},{"key":"2024092815515803600_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0039-6060(05)80345-9","article-title":"Postinjury neutrophil priming and activation: an early vulnerable window","volume":"118","author":"Botha","year":"1995","journal-title":"Surgery"},{"key":"2024092815515803600_bib3","first-page":"412","article-title":"Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure","volume":"39","author":"Botha","year":"1995","journal-title":"J Trauma"},{"key":"2024092815515803600_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00024382-199503000-00001","article-title":"Postinjury neutrophil priming and activation states. 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