{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:28:05Z","timestamp":1761290885854},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A personal series is reported of 52 patients who underwent proximal pancreatoduodenectomy for severe chronic pancreatitis between 1979 and 1994. There were 13 women and 39 men of median age 42\u00b72 (range 12\u201370) years. Disease predominantly affected the head of pancreas, with calcification present in 37 patients. Indications for operation were chronic pain (47 patients), obstructive jaundice (19) and duodenal stenosis (six); cancer was suspected in 12. In addition, 14 patients had a pseudocyst, two pancreatic endocrine failure and 20 exocrine failure. Aetiology was chronic alcohol abuse in 34, recurrent acute pancreatitis in five and unknown in 13. Pylorus-preserving proximal pancreatoduodenectomy was performed in 45 patients, while the remaining seven had partial gastrectomy. Drainage of a dilated distal pancreatic duct by side-to-side pancreaticojejunal anastomosis was included in 15 patients. Mean operating time was 6\u00b72 (range 4\u00b75\u20139\u00b75) h and mean blood loss was 2\u00b77 (range 0\u00b72\u201313\u00b70) litres. There were no hospital deaths, but three patients required a second operation and five had percutaneous drainage of infected collections. During a median follow-up of 54 months, six patients required completion distal pancreatectomy for renewed pain and four others had persistent pain. Four patients required intervention for stricture at the biliary-enteric anastomosis. Ten patients have died from causes not directly related to chronic pancreatitis. Proximal pancreatoduodenectomy is a relatively safe procedure, effectively palliating pain in 80 per cent of patients with chronic pancreatitis.<\/jats:p>","DOI":"10.1002\/bjs.1800831035","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T10:51:33Z","timestamp":1172746293000},"page":"1433-1440","source":"Crossref","is-referenced-by-count":41,"title":["Proximal pancreatoduodenectomy for chronic pancreatitis"],"prefix":"10.1093","volume":"83","author":[{"given":"G N","family":"Stapleton","sequence":"first","affiliation":[{"name":"Department of Surgery, Hammersmith Hospital and Royal Postgraduate Medical School , Du Cane Road, London W12 0NN,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C N","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hammersmith Hospital and Royal Postgraduate Medical School , Du Cane Road, London W12 0NN,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"2024092816193307100_bib1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/bjs.1800701212","article-title":"Coeliac plexus block for pain in pancreatic cancer and chronic pancreatitis","volume":"70","author":"Leung","year":"1983","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1055\/s-2007-1009042","article-title":"Extracorporeal shock-wave lithotripsy of pancreatic duct stones: immediate and long-term results","volume":"26","author":"van der Hul","year":"1994","journal-title":"Endoscopy"},{"key":"2024092816193307100_bib3","first-page":"2042","article-title":"Piezoelectric shock wave lithotripsy of pancreatic duct stones","volume":"89","author":"Schneider","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2024092816193307100_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF01670548","article-title":"Long-term results of side-to-side pancreaticojejunostomy","volume":"14","author":"Greenlee","year":"1990","journal-title":"World J Surg"},{"key":"2024092816193307100_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/bjs.1800711008","article-title":"Drainage operations in chronic pancreatitis","volume":"71","author":"Cooper","year":"1984","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bjs.1800741013","article-title":"Total pancreatectomy for chronic pancreatitis","volume":"74","author":"Cooper","year":"1987","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bjs.1800740112","article-title":"Duodenum-preserving total pancreatectomy for end stage chronic pancreatitis","volume":"74","author":"Lambert","year":"1987","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib8","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/bjs.1800821037","article-title":"Role of total pancreatectomy in the treatment of patients with end-stage chronic pancreatitis","volume":"82","author":"Fleming","year":"1995","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib9","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/bjs.1800740919","article-title":"Resection in chronic pancreatitis","volume":"74","author":"Williamson","year":"1987","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/bjs.1800750522","article-title":"Surgical management of chronic pancreatitis: long-term results in 141 patients","volume":"75","author":"Mannell","year":"1988","journal-title":"Br J Surg"},{"key":"2024092816193307100_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01670546","article-title":"Chronic pancreatitis: results of operations for relief of pain","volume":"14","author":"Ihse","year":"1990","journal-title":"World J Surg"},{"key":"2024092816193307100_bib12","first-page":"467","article-title":"Duodenum-preserving resection of the head of the pancreas in patients with severe chronic pancreatitis","volume":"97","author":"Beger","year":"1985","journal-title":"Surgery"},{"key":"2024092816193307100_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00000658-198903000-00004","article-title":"Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. 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