{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:46:10Z","timestamp":1760013970616},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although the operation of choice for patients with familial adenomatous polyposis (FAP) is restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA), its place in the management of patients with FAP and cancer has not been defined. The authors have reviewed their experience with these patients to determine the safety of IPAA and its efficacy as a cancer operation. The records of 55 patients with FAP who had undergone IPAA were examined. Follow-up studies included an annual questionnaire and physical examination. Eight patients had FAP with coexisting colorectal cancer. Median age at diagnosis was 25 (range 13\u201346) years, and at operation 33 (range 22\u201336) years. Of the eight patients (four men), four had colonic cancer and four had rectal cancer. Synchronous colorectal carcinoma was found in two patients. Staging according to the tumour node metastasis classification showed that five patients had stage 1 tumour, two had stage 2 and one had stage 3. Tumours were well, moderately or poorly differentiated in one, five and two patients respectively. During a median follow-up of 56 (range 14\u201398) months, metastasis developed in the liver of one patient 66months after surgery. Two patients suffered complications: one had small bowel obstruction and the other mucosal prolapse. Tubular adenomas were found in the pouch of two patients and in the anal transitional zone of one. Pouch function is good to excellent in all surviving patients. Restorative proctocolectomy for patients with FAP and coexisting colorectal cancer can be undertaken with a favourable prognosis and function. It is compatible with curative intent.<\/jats:p>","DOI":"10.1002\/bjs.1800831128","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T22:19:29Z","timestamp":1172701169000},"page":"1578-1580","source":"Crossref","is-referenced-by-count":23,"title":["Results after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with familial adenomatous polyposis and coexisting colorectal cancer"],"prefix":"10.1093","volume":"83","author":[{"given":"Y","family":"Ziv","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Oakley","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"McGannon","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T K","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V F","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgey A111, The Cleveland Clinic Foundation , 9500 Euclid Avenue, Cleveland, Ohio 44 195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"2024092815590532100_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.33.1.125","article-title":"Overview of the screening and management of familial adenomatous polyposis","volume":"33","author":"Rhodes","year":"1992","journal-title":"Gut"},{"key":"2024092815590532100_bib2","first-page":"20","article-title":"Colectomy with ilcorectal anastomosis for familial adenomatous polyposis: the risk of rectal cancer","volume":"101","author":"Sarre","year":"1987","journal-title":"Surgery"},{"key":"2024092815590532100_bib3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/bjs.1800791245","article-title":"Rectal cancer risk in patients treated for familial adenomatous polyposis","volume":"79","author":"De 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Surg"},{"key":"2024092815590532100_bib11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/bjs.1800780708","article-title":"Comparison of morbidity and function after colectomy with ileorectal anastomosis or restorative proctocolectomy for familial adenomatous polyposis","volume":"78","author":"Madden","year":"1987","journal-title":"Br J Surg"},{"key":"2024092815590532100_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF02564884","article-title":"Ileal pouch-anal anastomosis for chronic ulcerative colitis and familial adenomatous polyposis coli complicated by adenocarcinoma","volume":"31","author":"Taylor","year":"1988","journal-title":"Dis Colon Rectum"},{"key":"2024092815590532100_bib13","first-page":"22","article-title":"Primary ileal pouch-anal and colorectal cancer \u2014 results and contraindications","volume":"35","author":"Fozard","year":"1992","journal-title":"Dis Colon 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