{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:40:56Z","timestamp":1790073656579,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005992","name":"Ministry of Education, Science and Culture","doi-asserted-by":"crossref","award":["05 671 062"],"award-info":[{"award-number":["05 671 062"]}],"id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Reduced expression of E-cadherin is associated with tumour invasiveness and metastasis. To elucidate whether E-cadherin expression correlates with clinical outcome in patients with oesophageal cancer, 62 patients were investigated immunohistochemically using an anti-E-cadherin monoclonal antibody (HECD-1). Eight patients had normal levels of expression in the tumour, 25 had tumours that expressed high levels (50 per cent or more tumour cells staining positive for E-cadherin) and 29 had tumours expressing low levels (less than 50 per cent of cells expressing E-cadherin). Patients with normally expressing tumours had a better prognosis at 3 years than those with low-expressing tumours (P &amp;lt; 0\u00b705). Postoperative death was correlated significantly with lymphatic invasion, lymph node metastasis, E-cadherin expression and depth of invasion (P &amp;lt; 0\u00b705). Furthermore, haematogenous recurrence was correlated with E-cadherin expression (rs = 0\u00b738, P &amp;lt; 0\u00b701) and blood vessel invasion (rs = 0\u00b728, P &amp;lt; 0\u00b705). These results suggest that evaluation of E-cadherin immunoreactivity may predict haematogenous recurrence and poor prognosis in patients with oesophageal cancer.<\/jats:p>","DOI":"10.1002\/bjs.1800831138","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:49:04Z","timestamp":1172699344000},"page":"1608-1614","source":"Crossref","is-referenced-by-count":77,"title":["Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus"],"prefix":"10.1093","volume":"83","author":[{"given":"S","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Surgery II, Osaka University Medical School , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Osaka University Medical School , 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