{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:27:56Z","timestamp":1761290876881},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Knoll, Amsterdam, The Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n A comparative study was performed between patients with exocrine pancreatic insufficiency after conventional pancreatoduodenectomy (Whipple\u2032s procedure) and pylorus-preserving pancreatoduodenectomy (PPPD). In these patients the pharmacodynamics of 2-mm enteric-coated pancreatin microspheres (ECPMs) and their gastric transit time in relation to that of a solid meal were investigated. The efficacy of ECPM preparations may differ after Whipple\u2032s procedure compared with PPPD, because the latter procedure does not include gastrectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Gastric transit was assessed by double-isotope scintigraphy. A pancake meal was labelled with 99mTc. ECPMs were cold-labelled with 170Er and neutron activated shortly before ingestion to enable imaging with a \u03b4 camera. Intraluminal pancreatic enzyme activity was assessed during a 6-h period with two indirect tests: the cholesteryl [14C]octanoate breath test and the N-benzoyl-L-tyrosyl-p-aminobenzoic acid-p-aminosalicylic acid (NBT-PABA-PAS) test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In patients who had Whipple's procedure, the gastric transit time of ECPMs and of the pancake meal was not significantly different. The outcome of the indirect pancreatic function tests during enzyme supplementation was comparable, and not significantly different, from that in healthy volunteers. In patients who had PPPD, however, the gastric transit time of microspheres was greatly delayed compared with that of the pancake meal (P&lt;0\u00b705). Improvement in the outcome of the indirect pancreatic function tests during enzyme supplementation was much less and remained well below that of healthy volunteers (P &lt; 0\u00b705).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In cases of exocrine pancreatic insufficiency after Whipple's procedure, 2-mm ECPM treatment adequately restores pancreatic enzyme activity. Following PPPD, however, ECPM treatment is often ineffective because the microspheres are retained in the stomach. In these patients, use of conventional powdered pancreatin enzyme preparations may improve the efficacy of treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bjs.1800840712","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T19:33:11Z","timestamp":1150486391000},"page":"952-956","source":"Crossref","is-referenced-by-count":19,"title":["Comparative effects of enteric-coated pancreatin microsphere therapy after conventional and pylorus-preserving pancreatoduodenectomy"],"prefix":"10.1093","volume":"84","author":[{"given":"M J","family":"Bruno","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J J","family":"Borm","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F J","family":"Hoek","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Delzenne","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A F","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Surgety, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J M","family":"de Goeij","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of California , San Diego,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"van Royen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"van Gulikt","sequence":"additional","affiliation":[{"name":"Interfaculty Reactor Institute, Delft University of Technology , Delft,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Th","family":"de Wit","sequence":"additional","affiliation":[{"name":"Interfaculty Reactor Institute, Delft University of Technology , Delft,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Goumat","sequence":"additional","affiliation":[{"name":"Interfaculty Reactor Institute, Delft University of Technology , Delft,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Alabama , Birmingham,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G N J","family":"Tytgat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Academic Medical Centre , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"2024092913460892300_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0002-9610(69)90283-9","article-title":"Digestive function after radical pancreaticoduodenectomy","volume":"117","author":"Fish","year":"1969","journal-title":"Am J Surg"},{"key":"2024092913460892300_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00000658-196810000-00010","article-title":"Pancreatico-duodenectomy; 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