{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:48Z","timestamp":1787063388144,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carotid endarterectomy is usually delayed for 2 months following an acute stroke, but the stroke may progress or a further stroke may occur. A randomized pilot study of urgent carotid surgery for acute stroke was undertaken to assess the feasibility of a definitive multicentre trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seven Manchester hospitals referred patients with acute stroke (less than 7 days previously), defined according to the Oxfordshire Community Strokc Project classification. The carotid arteries were examined by portable continuous-wave Doppler ultrasonography. Patients with more than 50 per cent carotid stenosis on portable Doppler ultrasonography underwent colour duplex Doppler imaging. Patients with more than 70\u201399 per cent carotid stenosis were randomized to urgent carotid surgery or best medical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 593 patients were assessed over 2 years. Of these, 414 had acute stroke, of whom 380 had probable cerebral infarction. Complete ipsilateral internal carotid artery occlusion was most common in patients with total anterior circulation infarcts (33 (28 per cent) of 117), whereas severe ipsilateral (70\u201399 per cent) stenosis was most common in partial anterior circulation infarcts (25 (20 per cent) of 128). Only 16 patients (one total and 15 partial anterior circulation infarcts) were fit enough for surgery and consented to randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A definitive trial of urgent carotid surgery would need to screen large numbers of patients but could focus on patients with partial anterior circulation infarcts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.1800840723","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T15:33:11Z","timestamp":1150471991000},"page":"990-992","source":"Crossref","is-referenced-by-count":30,"title":["Pilot study of carotid surgery for acute stroke"],"prefix":"10.1093","volume":"84","author":[{"given":"G E","family":"Mead","sequence":"first","affiliation":[{"name":"University Department of Surgery, University Hospital of South Manchester , Manchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Murray","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine, University Hospital of South Manchester , Manchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Farrell","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine, University Hospital of South Manchester , Manchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"O'Neill","sequence":"additional","affiliation":[{"name":"University Department of Surgery, University Hospital of South Manchester , Manchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C N","family":"McCollum","sequence":"additional","affiliation":[{"name":"University Department of Geriatric Medicine, University Hospital of South Manchester , Manchester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"2024092913590707300_bib1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0140-6736(91)92916-P","article-title":"MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70\u201399 per cent) or with mild (0\u201329 per cent) carotid stenosis","volume":"337","author":"European Carotid Surgery Trialists' Collaborative Group","year":"1991","journal-title":"Luncet"},{"key":"2024092913590707300_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM199108153250701","article-title":"Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis","volume":"325","author":"North American Symptomatic Carotid Endarterectomy Trial Collaborators","year":"1991","journal-title":"N Engl JMed"},{"key":"2024092913590707300_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3171\/jns.1964.21.3.0212","article-title":"Intracranial hemorrhage following surgical revascularization for treatment of acute strokes","volume":"21","author":"Wylie","year":"1964","journal-title":"J Neurosurg"},{"key":"2024092913590707300_bib4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00000658-196511000-00014","article-title":"Emergency operation for acute cerebral ischemia due to carotid artery obstruction: review of 26 cases","volume":"162","author":"Hunter","year":"1965","journal-title":"Ann Surg"},{"key":"2024092913590707300_bib5","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.1969.03160250045010","article-title":"Joint study of extracranial arterial occlusion. IV. A review of surgical considerations","volume":"209","author":"Blaisdell","year":"1969","journal-title":"JAMA"},{"key":"2024092913590707300_bib6","first-page":"862","article-title":"Operation for acute completed stroke due to thrombosis of the internal carotid artery","volume":"65","author":"Rob","year":"1969","journal-title":"Surgery"},{"key":"2024092913590707300_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/01.STR.9.6.599","article-title":"A new look at emergency caroti artery operations for treatment of cerebrovascular insufficiency","volume":"9","author":"Goldstone","year":"1978","journal-title":"Stroke"},{"key":"2024092913590707300_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0741-5214(94)70118-0","article-title":"Carotid endarterectomy for unstable and compelling neurologic conditions; do results justify an aggressive approach?","volume":"19","author":"Gertler","year":"1994","journal-title":"J Vasc SUT"},{"key":"2024092913590707300_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0741-5214(84)90011-9","article-title":"Early carotid endarterectomy in patients with small fixed neurological deficits","volume":"1","author":"Whittemore","year":"1984","journal-title":"J Vasc Surg"},{"key":"2024092913590707300_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0741-5214(90)90327-7","article-title":"Timing of carotid endarterectomy after acute stroke","volume":"11","author":"Piotrowski","year":"1990","journal-title":"J Vasc Surg"},{"key":"2024092913590707300_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0741-5214(85)90191-0","article-title":"Carotid endarterectomy in the stroke patient: computerized axial tomography to determine timing","volume":"2","author":"Dosick","year":"1985","journal-title":"J Vasc Surg"},{"key":"2024092913590707300_bib12","first-page":"103","article-title":"774 carotid endarterectomies for strokes and transient ischaemic attacks: comparison of results of early vs. late surgery","volume":"42","author":"Khanna","year":"1988","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"2024092913590707300_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0950-821X(05)80950-8","article-title":"Urgent carotid surgery for high risk patients","volume":"7","author":"Greenhalgh","year":"1993","journal-title":"Eur J Vasc Surg"},{"key":"2024092913590707300_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0741-5214(94)90018-3","article-title":"Early endarterectomy for severe carotid artery stenosis after a nondisabling stroke: results from the North American Symptomatic Carotid Endarterectomy Trial","volume":"20","author":"Gasecki","year":"1994","journal-title":"J Vasc Surg"},{"key":"2024092913590707300_bib15","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0140-6736(91)93206-O","article-title":"Classification and natural history of clinically identifiable subtypes of cerebral infarction","volume":"337","author":"Bamford","year":"1991","journal-title":"Lancet"},{"key":"2024092913590707300_bib16","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1136\/bmj.302.6792.1565","article-title":"Siriraj stroke score and validation study to distinguish supratentorial intracerebral haemorrhage from infarction","volume":"302","author":"Poungvarin","year":"1991","journal-title":"BMJ"},{"key":"2024092913590707300_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/01.STR.26.6.1007","article-title":"Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy","volume":"26","author":"Saunders","year":"1995","journal-title":"Stroke"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800840723","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800840723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/84\/7\/990\/59431707\/bjs1800840723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/84\/7\/990\/59431707\/bjs1800840723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T09:59:16Z","timestamp":1727603956000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/84\/7\/990\/6171222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7,1]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1997,7,1]]},"published-print":{"date-parts":[[1997,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800840723","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,7]]},"published":{"date-parts":[[1997,7,1]]}}}