{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:49:56Z","timestamp":1770738596746,"version":"3.49.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Total colectomy with an ileorectal anastomosis (IRA) is a commonly performed operation. Postoperative mortality and morbidity are reported to be low and functional outcome is generally rated as good to excellent. The aim of this study was to review postoperative mortality, morbidity and functional results in an effort to identify risk factors predictive of a poor outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Some 215 patients (118 women and 97 men) with a median age of 33 (interquartile range (i.q.r.) 25\u201347) years underwent an IRA between November 1990 and December 1999. Median follow-up was 2 years 9 months (i.q.r. 1\u20135 years). The clinical notes of these patients were reviewed retrospectively to analyse the postoperative course, bowel function and long-term clinical outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The indications for surgery included familial adenomatous polyposis (52\u00b71 per cent), Crohn's disease (14\u00b74 per cent), functional bowel disorder (14\u00b74 per cent), ulcerative colitis (8\u00b74 per cent) and colonic carcinoma (4\u00b77 per cent). The overall 30-day mortality and morbidity rates were 0\u00b79 and 26\u00b70 per cent respectively. This included anastomotic leak (6\u00b75 per cent), small bowel obstruction (14\u00b74 per cent), fistula (2\u00b78 per cent) and anastomotic stricture (1\u00b74 per cent). The incidence of fistula and anastomotic stricture was significantly higher in Crohn's disease (P &amp;lt; 0\u00b7001 and P = 0\u00b7005 respectively). Only 16 of 31 patients with Crohn's disease had a functioning IRA at long-term follow-up. Median stool frequency was 3 (i.q.r. 3\u20135) per day one year following surgery and did not change with longer follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Mortality and morbidity rates following IRA are low. Postoperative fistula and anastomotic stricture are more common in patients with Crohn's disease, approximately half of whom will eventually need a permanent ileostomy. Long-term bowel function for all groups is satisfactory.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4005","type":"journal-article","created":{"date-parts":[[2003,1,14]],"date-time":"2003-01-14T16:16:07Z","timestamp":1042560967000},"page":"59-65","source":"Crossref","is-referenced-by-count":78,"title":["Mortality, morbidity and functional outcome after ileorectal anastomosis"],"prefix":"10.1093","volume":"90","author":[{"given":"C","family":"Elton","sequence":"first","affiliation":[{"name":"Department of Surgery, St Mark's Hospital , Harrow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Makin","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Mark's Hospital , Harrow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hitos","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Mark's Hospital , Harrow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R G","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Mark's Hospital , Harrow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2024093006434346100_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02238251","article-title":"Clinical outcome and bowel function following total abdominal colectomy and ileorectal anastomosis in the oriental population","volume":"41","author":"Eu","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"2024093006434346100_bib2","first-page":"231","article-title":"Total colectomy with ileorectal anastomosis (IRA): our experience in 57 patients","volume":"17","author":"Iacconi","year":"1996","journal-title":"G 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