{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:04:55Z","timestamp":1790881495159,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T00:00:00Z","timestamp":1043712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of the present study was to identify the clinicopathological and molecular biological characteristics of early-onset colorectal cancers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The clinicopathological and molecular biological parameters of 138 consecutive patients with colorectal cancer aged less than 40 years were compared with those of 339 patients aged 60 years or more.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The younger patients with colorectal cancer had more mucin-producing (14\u00b75 versus 4\u00b77 per cent; P &amp;lt; 0\u00b7001) and poorly differentiated (7\u00b72 versus 3\u00b73 per cent; P = 0\u00b7015) tumours, a higher incidence of synchronous (5\u00b78 versus 1\u00b72 per cent; P = 0\u00b7007) and metachronous (4\u00b70 versus 0\u00b76 per cent; P = 0\u00b7023) colorectal cancers, and more advanced tumour stage (P &amp;lt; 0\u00b7001) than older patients. The operative mortality rate was lower (0\u00b77 versus 5\u00b70 per cent; P = 0\u00b7026), and cancer-specific survival was similar (in stage I, II and III disease; P &amp;gt; 0\u00b705) or better (in stage IV disease; 95 per cent confidence interval 22\u00b750 to 28\u00b741 versus 12\u00b761 to 17\u00b705 months; P &amp;lt; 0\u00b7001). There was a higher percentage of normal p53 expression (61\u00b71 versus 46\u00b78 per cent; P = 0\u00b7023) and high-frequency microsatellite instability (MSI-H) (29\u00b74 versus 6\u00b73 per cent; P &amp;lt; 0\u00b7001), and a similar family history of cancer (17\u00b75 versus 14\u00b72 per cent; P &amp;gt; 0\u00b705), compared with older patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Young patients with colorectal cancer have several distinct clinicopathological and molecular biological features. The mechanisms underlying the inconsistency between the presence of MSI-H and a family history of cancer in these early-onset colorectal cancers deserve further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4015","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T15:33:23Z","timestamp":1043854403000},"page":"205-214","source":"Crossref","is-referenced-by-count":162,"title":["Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age"],"prefix":"10.1093","volume":"90","author":[{"given":"J T","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K C","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, National Taiwan University Hospital, 7 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