{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:52:36Z","timestamp":1760266356004},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fine-needle aspiration cytology (FNAC) is useful for selecting patients with thyroid nodules for thyroidectomy. Its value in patients who have been exposed to low-dose therapeutic radiation is questionable because these patients have an increased risk of multifocal benign and malignant tumours, and thyroid cancer is common in such patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 1960 and 1999, 171 patients with one or more thyroid nodules who had a history of exposure to radiation underwent operation; 49 of these patients had preoperative FNAC. The cytology results in these 49 patients were compared with those of an age- and sex-matched control group of patients with thyroid nodules who did not have a history of radiation exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of those who had been exposed to radiation, six of 20 patients with \u2018benign\u2019 cytology by FNAC and six of 16 patients with \u2018suspicious\u2019 cytology had thyroid cancer. All 13 specimens considered to be malignant on FNAC were indeed malignant. There was a higher rate of false-negative cytological examinations among patients with a history of irradiation that in those without.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FNAC of thyroid nodules in patients with a history of irradiation is not as accurate as that in non-irradiated patients, primarily because of coexisting occult thyroid cancers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4198","type":"journal-article","created":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T10:09:56Z","timestamp":1055239796000},"page":"755-758","source":"Crossref","is-referenced-by-count":10,"title":["Accuracy of fine-needle aspiration cytology in patients with radiation-induced thyroid neoplasms"],"prefix":"10.1093","volume":"90","author":[{"given":"S","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Medical Staff Unit, Japan Defense Agency, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N D","family":"Perrier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Wake Forest University Medical Center, Winston-Salem, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H G","family":"Ituarte","sequence":"additional","affiliation":[{"name":"Center for Health and Environment, University of California, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Treseler","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California San Francisco Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Siperstein","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA"},{"name":"Department of Pathology, University of California San Francisco Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q-Y","family":"Duh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California San Francisco Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F S","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Medicine and Radiology, University of California San Francisco Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O H","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California San Francisco Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,6,9]]},"reference":[{"key":"2021070911361245700_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0196-0709(83)80006-4","article-title":"The solitary thyroid nodule: diagnosis and management of malignant disease","volume":"4","author":"Lawson","year":"1983","journal-title":"Am J Otolaryngol"},{"key":"2021070911361245700_bib2","first-page":"147","article-title":"Evaluation of the thyroid nodule","volume":"33","author":"Cannon","year":"1986","journal-title":"Am Fam Physician"},{"key":"2021070911361245700_bib3","first-page":"129","article-title":"The thyroid nodule. 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