{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:07:56Z","timestamp":1789920476392,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T00:00:00Z","timestamp":1060646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to determine whether leakage from a colorectal anastomosis following potentially curative anterior resection for rectal cancer is an independent risk factor for local recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included all patients who had a potentially curative anterior resection with anastomosis for adenocarcinoma of the rectum between 1971 and 1991 at Concord Hospital. The data were collected prospectively, with complete follow-up for at least 5 years. The Kaplan\u2013Meier method was used to compare time to recurrence between strata of categorical variables. Proportional hazards regression was used in multivariate modelling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 403 patients in the study. After adjustment for lymph node metastases, the distal resection margin of resection, non-total anatomical dissection of the rectum and the level of anastomosis, multivariate analysis identified a significant association between anastomotic leakage and local recurrence (hazard ratio 3\u00b78, 95 per cent confidence interval 1\u00b78 to 7\u00b79).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Leakage following a colorectal anastomosis after potentially curative resection for adenocarcinoma of the rectum is an independent predictor of local recurrence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4219","type":"journal-article","created":{"date-parts":[[2003,9,23]],"date-time":"2003-09-23T10:38:35Z","timestamp":1064313515000},"page":"1261-1266","source":"Crossref","is-referenced-by-count":266,"title":["Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence"],"prefix":"10.1093","volume":"90","author":[{"given":"S W","family":"Bell","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J F X","family":"Rickard","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O F","family":"Dent","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Bokey","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The University of Sydney, Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,8,12]]},"reference":[{"key":"2021070911373291100_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00341385","article-title":"Anastomotic leaks in colorectal surgery: a risk factor for recurrence?","volume":"6","author":"Akyol","year":"1991","journal-title":"Int J Colorectal Dis"},{"key":"2021070911373291100_bib2","first-page":"229","article-title":"Anastomotic leakage after colorectal surgery: a risk factor for recurrence and poor prognosis","volume":"23","author":"Fujita","year":"1993","journal-title":"Jpn J Clin Oncol"},{"key":"2021070911373291100_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00000658-199502000-00008","article-title":"Comparison of manually constructed and stapled anastomoses in colorectal surgery. 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