{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:55:14Z","timestamp":1762160114111},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T00:00:00Z","timestamp":1067817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fresenius AG, Bed Homburg, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The formation of further adhesions after adhesiolysis is a major problem. Not all agents that are supposed to reduce de novo adhesions can reduce further adhesion formation. The efficacy and safety of intraperitoneally applied phospholipids has been shown previously. This study evaluated the influence of phospholipids and icodextrin on adhesion re-formation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In an experimental study on 60 Chinchilla rabbits adhesions were induced by standardized abrasion of defined areas of the ventral abdominal wall, the caecum and the ileum. Open adhesiolysis was performed 10 days later. The animals randomly received either 1\u00b75 per cent phospholipids, 4 per cent icodextrin or Ringer's lactate intraperitoneally. Half of the animals in each group were killed after a further 10 days and the remainder at 20 days. Adhesion formation was assessed by computer-aided planimetry and histopathological examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Phospholipids (10 days: P = 0\u00b7001; 20 days: P = 0\u00b7012) and icodextrin (10 days: P = 0\u00b7006; 20 days: P = 0\u00b7055) reduced adhesion re-formation after both intervals compared with Ringer's lactate controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Phospholipids and icodextrin were effective in preventing re-formation of adhesions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4316","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T22:10:49Z","timestamp":1069452649000},"page":"1604-1607","source":"Crossref","is-referenced-by-count":27,"title":["Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions"],"prefix":"10.1093","volume":"90","author":[{"given":"S A","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Treutner","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Anurov","sequence":"additional","affiliation":[{"name":"Joint Institute for Surgical Research, Russian Medical State University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Titkova","sequence":"additional","affiliation":[{"name":"Joint Institute for Surgical Research, Russian Medical State University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Oettinger","sequence":"additional","affiliation":[{"name":"Joint Institute for Surgical Research, Russian Medical State University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Schumpelick","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,11,3]]},"reference":[{"key":"2021070911434357000_bib1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/BF02237441","article-title":"Impact of previous surgery on time taken for incision and division of adhesions during laparotomy","volume":"43","author":"Coleman","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"2021070911434357000_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2168.2000.01394.x","article-title":"Morbidity and mortality of inadvertent enterotomy during adhesiotomy","volume":"87","author":"Van Der Krabben","year":"2000","journal-title":"Br J Surg"},{"key":"2021070911434357000_bib3","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0140-6736(98)09337-4","article-title":"Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study","volume":"353","author":"Ellis","year":"1999","journal-title":"Lancet"},{"key":"2021070911434357000_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s001040050848","article-title":"Prevention of adhesions. 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