{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T13:07:07Z","timestamp":1726405627773},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T00:00:00Z","timestamp":1081814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Gastro-oesophageal reflux disease (GORD) is a commonly underestimated aetiological factor in patients with respiratory symptoms. In this study, acid reflux in healthy volunteers and patients with GORD with and without respiratory symptoms was investigated by dual pH monitoring.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty healthy volunteers and 43 patients with GORD underwent oesophageal manometry and dual pH monitoring with one probe in the proximal and one in the distal oesophagus. Nineteen of the 43 patients complained of respiratory symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were no differences in proximal probe measurements between volunteers and patients without respiratory symptoms. Patients with GORD and respiratory symptoms had a higher prevalence of abnormally high exposure to gastric juice and more reflux episodes in the proximal oesophagus compared with patients with GORD and no respiratory symptoms. Some 17 of 19 patients with GORD and respiratory symptoms showed deteriorated oesophageal body motility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Dual pH monitoring is feasible and well tolerated, and provides an objective means of evaluating patients with GORD and respiratory symptoms. Prolonged exposure of the proximal oesophagus to gastric juice and disorders of oesophageal body motility seem to be responsible for the development of respiratory symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4551","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:43:03Z","timestamp":1081849383000},"page":"867-871","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of respiratory symptoms with dual pH monitoring in patients with gastro-oesophageal reflux disease"],"prefix":"10.1093","volume":"91","author":[{"given":"W K H","family":"Kauer","sequence":"first","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"M\u00f6bius","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Siewert","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,4,13]]},"reference":[{"key":"2021070911475094900_bib1","first-page":"65","volume-title":"Surgical Treatment of Digestive Disease","author":"DeMeester","year":"1989","edition":"2nd"},{"key":"2021070911475094900_bib2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/0016-5085(95)90646-0","article-title":"Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis","volume":"109","author":"Shaker","year":"1995","journal-title":"Gastroenterology"},{"key":"2021070911475094900_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1164\/ajrccm.164.1.2006002","article-title":"Prevalence of upper respiratory symptoms in patients with symptomatic gastroesophageal reflux disease","volume":"164","author":"Theodoropoulos","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2021070911475094900_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archsurg.1996.01430170035005","article-title":"Outcome of respiratory symptoms after antireflux surgery on patients with gastroesophageal reflux disease","volume":"131","author":"Johnson","year":"1996","journal-title":"Arch Surg"},{"key":"2021070911475094900_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1091-255X(01)80032-9","article-title":"Pharyngeal pH monitoring in 222 patients with suspected laryngeal reflux","volume":"5","author":"Eubanks","year":"2001","journal-title":"J Gastrointest Surg"},{"key":"2021070911475094900_bib6","first-page":"1503","article-title":"Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-hr ambulatory pH monitoring","volume":"84","author":"Wiener","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"2021070911475094900_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/003655200750024074","article-title":"24-h pharyngeal pH monitoring in healthy volunteers: a normative study","volume":"35","author":"Bove","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"2021070911475094900_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0016-5085(91)90196-R","article-title":"Proximal esophageal pH-metry in patients with \u2018reflux laryngitis\u2019","volume":"100","author":"Jacob","year":"1991","journal-title":"Gastroenterology"},{"key":"2021070911475094900_bib9","first-page":"1102","article-title":"Ambulatory 24-hour esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility","volume":"87","author":"Jamieson","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"2021070911475094900_bib10","first-page":"769","article-title":"Circadian esophageal motor function in patients with gastroesophageal reflux disease","volume":"108","author":"Stein","year":"1990","journal-title":"Surgery"},{"key":"2021070911475094900_bib11","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/archsurg.1992.01420070040010","article-title":"Effect of Nissen fundoplication on esophageal motor function","volume":"127","author":"Stein","year":"1992","journal-title":"Arch Surg"},{"key":"2021070911475094900_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-5223(05)80019-4","article-title":"A tailored approach to antireflux surgery","volume":"110","author":"Kauer","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021070911475094900_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0016-5085(19)32264-4","article-title":"Improved infusion system for intraluminal esophageal manometry","volume":"73","author":"Arndorfer","year":"1977","journal-title":"Gastroenterology"},{"key":"2021070911475094900_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0002-9610(88)80266-6","article-title":"The lower esophageal sphincter in health and disease","volume":"155","author":"Zaninotto","year":"1988","journal-title":"Am J Surg"},{"key":"2021070911475094900_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/000348948909800116","article-title":"Detection of gastroesophageal reflux in head and neck: the role of scintigraphy","volume":"98","author":"Kuriloff","year":"1989","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2021070911475094900_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00005537-199802000-00027","article-title":"Ambulatory pH measurement at the upper esophageal sphincter","volume":"108","author":"Smit","year":"1998","journal-title":"Laryngoscope"},{"key":"2021070911475094900_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0002-9610(01)00597-9","article-title":"Pharyngeal pH measurements in patients with respiratory symptoms before and during proton pump inhibitor therapy","volume":"181","author":"Eubanks","year":"2001","journal-title":"Am J Surg"},{"key":"2021070911475094900_bib18","first-page":"25","article-title":"Normal and abnormal proximal esophageal acid exposure: results of ambulatory dual-probe pH monitoring","volume":"88","author":"Dobhan","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2021070911475094900_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1013290715062","article-title":"Symptom predictability of reflux-induced respiratory disease","volume":"47","author":"Tomonaga","year":"2002","journal-title":"Dig Dis Sci"},{"key":"2021070911475094900_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0003489400109S1003","article-title":"Ambulatory pH monitoring methodology","volume":"184","author":"Postma","year":"2000","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2021070911475094900_bib21","first-page":"38","article-title":"Ambulatory esophageal and hypopharyngeal pH monitoring in patients with hoarseness","volume":"85","author":"Katz","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"2021070911475094900_bib22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0016-5085(99)70389-6","article-title":"Esophagopharyngeal acid regurgitation: dual pH monitoring criteria for its detection and insights into mechanisms","volume":"117","author":"Williams","year":"1999","journal-title":"Gastroenterology"},{"key":"2021070911475094900_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0892-1997(88)80060-2","article-title":"Reflux laryngitis and its sequelae: the diagnostic role of ambulatory 24-hour pH monitoring","volume":"2","author":"Koufman","year":"1988","journal-title":"J Voice"},{"key":"2021070911475094900_bib24","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/gut.28.9.1177","article-title":"Technical aspects of intraluminal pH-metry in man: current status and recommendations","volume":"28","author":"Emde","year":"1987","journal-title":"Gut"},{"key":"2021070911475094900_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/gut.28.8.935","article-title":"Electrodes for 24 hour pH monitoring: a comparative study","volume":"28","author":"McLauchlan","year":"1987","journal-title":"Gut"},{"key":"2021070911475094900_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0002-9610(92)90041-O","article-title":"Esophageal manometry and 24-hour pH monitoring in the diagnosis of pulmonary aspiration secondary to gastroesophageal reflux","volume":"163","author":"Patti","year":"1992","journal-title":"Am J Surg"},{"key":"2021070911475094900_bib27","first-page":"110","article-title":"Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy","volume":"86","author":"Pellegrini","year":"1979","journal-title":"Surgery"},{"key":"2021070911475094900_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0002-9610(05)80421-0","article-title":"Clinical and functional characterization of high gastroesophageal reflux","volume":"165","author":"Patti","year":"1993","journal-title":"Am J Surg"},{"key":"2021070911475094900_bib29","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/archsurg.1992.01420070040010","article-title":"Effect of Nissen fundoplication on esophageal motor function","volume":"127","author":"Stein","year":"1992","journal-title":"Arch Surg"},{"key":"2021070911475094900_bib30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0002-9610(97)00180-3","article-title":"Respiratory symptoms in patients with gastroesophageal reflux disease following medical therapy and following antireflux surgery","volume":"174","author":"Wetscher","year":"1997","journal-title":"Am J Surg"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4551","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/7\/867\/36729640\/bjs4551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/7\/867\/36729640\/bjs4551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T17:16:24Z","timestamp":1625850984000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/91\/7\/867\/6143628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,13]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2004,4,13]]},"published-print":{"date-parts":[[2004,6,17]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4551","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2004,7]]},"published":{"date-parts":[[2004,4,13]]}}}