{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:38:34Z","timestamp":1778121514146,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T00:00:00Z","timestamp":1084492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to compare laparoscopic and open Nissen fundoplication for gastro-oesophageal reflux disease in a randomized clinical trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ninety-nine patients were randomized to either laparoscopic (52) or open (47) Nissen fundoplication. Patients with oesophageal dysmotility, those requiring a concurrent abdominal procedure and those who had undergone previous antireflux surgery were excluded. Independent assessment of dysphagia, heartburn and patients' satisfaction 1, 3, 6 and 12 months after surgery was performed using multiple standardized clinical grading systems. Objective measurement of oesophageal acid exposure and lower oesophageal sphincter pressure before and after surgery, and endoscopic assessment of postoperative anatomy, were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Operating time was longer in the laparoscopic group (median 82 versus 46 min). Postoperative pain, analgesic requirement, time to solid food intake, hospital stay and recovery time were reduced in the laparoscopic group. Perioperative outcomes, postoperative dysphagia, relief of heartburn and overall satisfaction were equally good at all follow-up intervals. Reduction in oesophageal acid exposure, increase in lower oesophageal sphincter tone and improvement in endoscopic appearances were the same for the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The laparoscopic approach to Nissen fundoplication improved early postoperative recovery, with an equally good outcome up to 12 months.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4574","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T17:01:17Z","timestamp":1084554077000},"page":"975-982","source":"Crossref","is-referenced-by-count":119,"title":["Randomized clinical trial of laparoscopic <i>versus<\/i> open fundoplication for gastro-oesophageal reflux disease"],"prefix":"10.1093","volume":"91","author":[{"given":"R","family":"Ackroyd","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D I","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Troy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Treacy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Stoddard","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,5,14]]},"reference":[{"key":"2021070911510141700_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-198607000-00002","article-title":"Nissen fundoplication for gastroesophageal reflux disease. Evaluation of primary repair in 100 consecutive patients","volume":"204","author":"DeMeester","year":"1986","journal-title":"Ann Surg"},{"key":"2021070911510141700_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01565907","article-title":"Fundoplication for the treatment of gastroesophageal reflux in hiatal hernia","volume":"1","author":"Rossetti","year":"1977","journal-title":"World J Surg"},{"key":"2021070911510141700_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/archsurg.1985.01390300013002","article-title":"The floppy Nissen fundoplication. Effective long-term control of pathologic reflux","volume":"120","author":"Donahue","year":"1985","journal-title":"Arch Surg"},{"key":"2021070911510141700_bib4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1046\/j.1365-2168.1998.00829.x","article-title":"Antireflux surgery in the laparoscopic era","volume":"85","author":"Watson","year":"1998","journal-title":"Br J Surg"},{"key":"2021070911510141700_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archsurg.1995.01430030059011","article-title":"Patient satisfaction following laparoscopic and open antireflux surgery","volume":"130","author":"Rattner","year":"1995","journal-title":"Arch Surg"},{"key":"2021070911510141700_bib6","first-page":"385","article-title":"Clinical and physiologic comparison of laparoscopic and open Nissen fundoplication","volume":"180","author":"Peters","year":"1995","journal-title":"J Am Coll Surg"},{"key":"2021070911510141700_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s004649900386","article-title":"Laparoscopic versus conventional Nissen fundoplication. A prospective randomized study","volume":"11","author":"Laine","year":"1997","journal-title":"Surg Endosc"},{"key":"2021070911510141700_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S1072-7515(98)00328-7","article-title":"Comparison of costs between laparoscopic and open Nissen fundoplication: a prospective randomized study with a 3-month follow-up","volume":"188","author":"Heikkinen","year":"1999","journal-title":"J Am Coll Surg"},{"key":"2021070911510141700_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/110241599750007469","article-title":"Immune response after laparoscopic and conventional Nissen fundoplication","volume":"165","author":"Perttila","year":"1999","journal-title":"Eur J Surg"},{"key":"2021070911510141700_bib10","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00464-001-9101-y","article-title":"Laparoscopic versus open approach for Nissen fundoplication. A comparative study","volume":"16","author":"Chrysos","year":"2002","journal-title":"Surg Endosc"},{"key":"2021070911510141700_bib11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1046\/j.1365-2168.2000.01471.x","article-title":"Randomized clinical trial of laparoscopic versus open fundoplication: blind evaluation of recovery and discharge period","volume":"87","author":"Nilsson","year":"2000","journal-title":"Br J Surg"},{"key":"2021070911510141700_bib12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/003655201750162935","article-title":"Dysphagia and oesophageal clearance after laparoscopic versus open Nissen fundoplication. A randomized, prospective trial","volume":"36","author":"Luostarinen","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"2021070911510141700_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(99)03097-4","article-title":"Laparoscopic or conventional Nissen fundoplication for gastro-oesophageal reflux disease: randomized clinical trial. The Netherlands Antireflux Surgery Study Group","volume":"355","author":"Bais","year":"2000","journal-title":"Lancet"},{"key":"2021070911510141700_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/archsurg.136.2.180","article-title":"Laparoscopic Nissen fundoplication\u2014five-year results and beyond","volume":"136","author":"Lafullarde","year":"2001","journal-title":"Arch Surg"},{"key":"2021070911510141700_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1091-255X(01)80012-3","article-title":"Five- to eight-year outcome of the first laparoscopic Nissen fundoplications","volume":"5","author":"Bammer","year":"2001","journal-title":"J Gastrointest Surg"},{"key":"2021070911510141700_bib16","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/BF00188451","article-title":"Changing strategies in the performance of laparoscopic Nissen fundoplication as a result of experience with 230 operations","volume":"9","author":"Watson","year":"1995","journal-title":"Surg Endosc"},{"key":"2021070911510141700_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00000658-199408000-00004","article-title":"Laparoscopic Nissen fundoplication","volume":"220","author":"Jamieson","year":"1994","journal-title":"Ann Surg"},{"key":"2021070911510141700_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(05)73399-7","article-title":"Gastro-oesophageal reflux disease","volume":"356","author":"Bloechle","year":"2000","journal-title":"Lancet"},{"key":"2021070911510141700_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(05)73401-2","article-title":"Gastro-oesophageal reflux disease","volume":"356","author":"Gorecki","year":"2000","journal-title":"Lancet"},{"key":"2021070911510141700_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0140-6736(05)73404-8","article-title":"Gastro-oesophageal reflux disease","volume":"356","author":"de Beaux","year":"2000","journal-title":"Lancet"},{"key":"2021070911510141700_bib21","first-page":"582","article-title":"A report from a randomized study of open and laparoscopic 360\u00b0 fundoplication","volume":"10","author":"Franzen","year":"1996","journal-title":"Surg Endosc"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4574","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/8\/975\/36730066\/bjs4574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/8\/975\/36730066\/bjs4574.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T21:18:53Z","timestamp":1625865533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/91\/8\/975\/6143698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,14]]},"references-count":21,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2004,5,14]]},"published-print":{"date-parts":[[2004,7,27]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4574","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,8]]},"published":{"date-parts":[[2004,5,14]]}}}