{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:42:15Z","timestamp":1790109735050,"version":"4.0.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T00:00:00Z","timestamp":1087862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012151","name":"Research and Development Directorate at the University Hospitals of Leicester NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Abdominal aortic aneurysm (AAA) repair is associated with a systemic inflammatory response. This inflammatory response probably arises as a result of an ischaemia\u2013reperfusion injury to the legs and gastrointestinal tract. In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Blood was sampled from the femoral vein, portal vein and radial artery of 14 patients undergoing elective AAA repair at five time points during the procedure. Plasma was snap-frozen for subsequent batch analysis of interleukin (IL) 6.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The plasma IL-6 concentration rose steadily throughout the procedure at all three locations. The increase in plasma IL-6 was significantly greater in the portal vein than in the radial artery during ischaemia (P = 0\u00b7020). The plasma IL-6 concentration was also significantly higher in the portal vein than in the femoral vein (P &amp;lt; 0\u00b7001) and radial artery (P &amp;lt; 0\u00b7001) during reperfusion. There were no significant differences between radial artery and femoral vein IL-6 levels at any time point.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Ischaemia and reperfusion during AAA repair were associated with a marked increase in IL-6 concentration in the portal vein, suggesting that IL-6 was produced by the gastrointestinal tract.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4691","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T15:01:24Z","timestamp":1087916484000},"page":"1153-1156","source":"Crossref","is-referenced-by-count":28,"title":["Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs"],"prefix":"10.1093","volume":"91","author":[{"given":"M G A","family":"Norwood","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Bown","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Sayers","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,6,22]]},"reference":[{"key":"2021070911554517200_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/ejvs.2001.1352","article-title":"The inflammatory response and its consequence for the clinical outcome following aortic aneurysm repair","volume":"21","author":"Swartbol","year":"2001","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2021070911554517200_bib2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1067\/mva.2003.39","article-title":"The systemic inflammatory response syndrome, organ failure, and mortality after abdominal aortic aneurysm repair","volume":"37","author":"Bown","year":"2003","journal-title":"J Vasc Surg"},{"key":"2021070911554517200_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/ejvs.2001.1522","article-title":"Cytokines and inflammatory pathways in the pathogenesis of multiple organ failure following abdominal aortic aneurysm repair","volume":"22","author":"Bown","year":"2001","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2021070911554517200_bib4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/bja\/59.9.1093","article-title":"Complement and anaphylatoxin responses to cross-clamping of the aorta. Studies during general anaesthesia with or without extradural blockade","volume":"59","author":"Bengtson","year":"1987","journal-title":"Br J Anaesth"},{"key":"2021070911554517200_bib5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00005373-198607000-00007","article-title":"Altered anaphylatoxin activity during induced hypoperfusion in acute and elective abdominal aortic surgery","volume":"26","author":"Bengtson","year":"1986","journal-title":"J Trauma"},{"key":"2021070911554517200_bib6","first-page":"847","article-title":"Neutrophil leukotriene generation and pulmonary dysfunction after abdominal aortic aneurysm repair","volume":"116","author":"Gadaleta","year":"1994","journal-title":"Surgery"},{"key":"2021070911554517200_bib7","first-page":"513","article-title":"Immunological and physical responses to aortic surgery: effect of reperfusion on neutrophil and monocytes activation and pulmonary function","volume":"84","author":"Barry","year":"1997","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1078-5884(97)80105-0","article-title":"Surgical management of 671 abdominal aortic aneurysms: a 13-year review from a single centre","volume":"13","author":"Sayers","year":"1997","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2021070911554517200_bib9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/bjs.1800810408","article-title":"Ruptured aortic aneurysm: early postoperative prediction of mortality using an organ system failure score","volume":"81","author":"Meesters","year":"1994","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1046\/j.0007-1323.2001.01927.x","article-title":"Pro- and anti-inflammatory cytokine release in open versus endovascular repair of abdominal aortic aneurysm","volume":"88","author":"Rowlands","year":"2001","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib11","first-page":"615","article-title":"Interleukin 6 production by the colon is a response to sigmoid ischaemia","volume":"81","author":"Green","year":"1994","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib12","first-page":"1235","article-title":"Portal endotoxin and cytokine responses to abdominal aortic surgery","volume":"79","author":"Baigrie","year":"1992","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/bjs.1800780327","article-title":"POSSUM: a scoring system for surgical audit","volume":"78","author":"Copeland","year":"1991","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib14","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"2021070911554517200_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0046-8177(92)90317-V","article-title":"Neutrophils as mediators of human skeletal muscle ischemia\u2013reperfusion syndrome","volume":"23","author":"Formigli","year":"1992","journal-title":"Hum Pathol"},{"key":"2021070911554517200_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/01913129509064221","article-title":"Expression of E-selectin in ischemic and reperfused human skeletal muscle","volume":"19","author":"Formigli","year":"1995","journal-title":"Ultrastruct Pathol"},{"key":"2021070911554517200_bib17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0002-9610(97)89593-1","article-title":"Vitamin E protects human skeletal muscle from damage during surgical ischemia\u2013reperfusion","volume":"173","author":"Novelli","year":"1997","journal-title":"Am J Surg"},{"key":"2021070911554517200_bib18","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/1043-4666(93)90034-3","article-title":"High levels of portal TNF-alpha during abdominal aortic surgery in man","volume":"5","author":"Cabie","year":"1993","journal-title":"Cytokine"},{"key":"2021070911554517200_bib19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1053\/ejvs.2000.1063","article-title":"Intestinal manipulation during elective aortic aneurysm surgery leads to portal endotoxaemia and mucosal barrier dysfunction","volume":"19","author":"Lau","year":"2000","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2021070911554517200_bib20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1053\/ejvs.2001.1304","article-title":"Extraperitoneal approach reduces neutrophil activation, systemic inflammatory response and organ dysfunction after aortic aneurysmal surgery","volume":"21","author":"Lau","year":"2001","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2021070911554517200_bib21","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2168.1998.00791.x","article-title":"Histological study of colonic ischaemia after aortic surgery","volume":"85","author":"Welch","year":"1998","journal-title":"Br J Surg"},{"key":"2021070911554517200_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/11024150260102807","article-title":"Role of the neutrophil in septic shock and the adult respiratory distress syndrome","volume":"168","author":"Aldridge","year":"2002","journal-title":"Eur J Surg"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4691","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/9\/1153\/36729882\/bjs4691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/9\/1153\/36729882\/bjs4691.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T21:22:17Z","timestamp":1625865737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/91\/9\/1153\/6143802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,22]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2004,6,22]]},"published-print":{"date-parts":[[2004,8,20]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4691","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,9]]},"published":{"date-parts":[[2004,6,22]]}}}