{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T03:54:36Z","timestamp":1767585276833},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Cancer Research Campaign","award":["SP2516\/0101"],"award-info":[{"award-number":["SP2516\/0101"]}]},{"name":"Newcastle University Hospitals Special Trustees"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to determine the feasibility and accuracy of sentinel lymph node (SLN) biopsy for oesophageal adenocarcinoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifty-seven patients with adenocarcinoma of the lower oesophagus (n = 40) or gastric cardia (n = 17) underwent endoscopic peritumoral injection of 99mTc-radiolabelled nanocolloid before en bloc resection with extended lymphadenectomy. SLNs were identified during surgery using a handheld \u03b3 probe and the pattern of radioactive uptake was quantified after operation. All 1667 resected lymph nodes were examined immunohistochemically for micrometastases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SLNs were identified in all 57 patients. They contained metastases (n = 32) or micrometastases (n = 3) in 35 of 37 node-positive patients and there were two false-negative studies. The overall accuracy of SLN biopsy was 96 per cent and SLNs were more likely to contain tumour than other lymph nodes (P &amp;lt; 0\u00b7001). Tumour-infiltrated nodal stations had a higher proportion of radioactive uptake (P &amp;lt; 0\u00b7001). Lower oesophageal tumours had a greater proportion of SLNs (P = 0\u00b7018), radioactive uptake (P &amp;lt; 0\u00b7001) and malignant nodes (P = 0\u00b7004) in the mediastinum than gastric cardia tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The sentinel node concept is applicable to oesophageal adenocarcinoma and could be used to tailor the extent of lymphadenectomy. There is a close relationship between patterns of radioactive uptake and lymphatic tumour dissemination, which differ for lower oesophageal and gastric cardia tumours.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4693","type":"journal-article","created":{"date-parts":[[2004,12,6]],"date-time":"2004-12-06T18:22:56Z","timestamp":1102357376000},"page":"60-67","source":"Crossref","is-referenced-by-count":66,"title":["Sentinel node biopsy to evaluate the metastatic dissemination of oesophageal adenocarcinoma"],"prefix":"10.1093","volume":"92","author":[{"given":"P J","family":"Lamb","sequence":"first","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Griffin","sequence":"additional","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A D","family":"Burt","sequence":"additional","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Karat","sequence":"additional","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Hayes","sequence":"additional","affiliation":[{"name":"Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary , Newcastle upon Tyne,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2024093006361329700_bib1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2","article-title":"Changing patterns in the incidence of esophageal and gastric carcinoma in the United States","volume":"83","author":"Devesa","year":"1998","journal-title":"Cancer"},{"key":"2024093006361329700_bib2","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa022343","article-title":"Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus","volume":"347","author":"Hulscher","year":"2002","journal-title":"N Engl J Med"},{"key":"2024093006361329700_bib3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00000658-200110000-00011","article-title":"Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies","volume":"234","author":"Hagen","year":"2001","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00000658-200111000-00001","article-title":"Should en bloc esophagectomy be the standard of care for esophageal carcinoma?","volume":"234","author":"Altorki","year":"2001","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/00000658-200012000-00002","article-title":"Limited resection for early adenocarcinoma in Barrett's esophagus","volume":"232","author":"Stein","year":"2000","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000658-200003000-00003","article-title":"Columnar mucosa and intestinal metaplasia of the esophagus: fifty years of controversy","volume":"231","author":"DeMeester","year":"2000","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/archsurg.1992.01420040034005","article-title":"Technical details of intraoperative lymphatic mapping for early stage melanoma","volume":"127","author":"Morton","year":"1992","journal-title":"Arch Surg"},{"key":"2024093006361329700_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1056\/NEJM199810013391401","article-title":"The sentinel node in breast cancer\u2014a multicenter validation study","volume":"339","author":"Krag","year":"1998","journal-title":"N Engl J Med"},{"key":"2024093006361329700_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00000658-199910000-00001","article-title":"Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group","volume":"230","author":"Morton","year":"1999","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00000658-200102000-00015","article-title":"Sentinel lymph node biopsy in the management of patients with primary cutaneous melanoma: review of a large single institutional experience with an emphasis on recurrence","volume":"233","author":"Clary","year":"2001","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib11","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1200\/JCO.1997.15.6.2345","article-title":"Sentinel lymphadenectomy in breast cancer","volume":"15","author":"Giuliano","year":"1997","journal-title":"J Clin Oncol"},{"key":"2024093006361329700_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00000658-199709000-00006","article-title":"Histopathologic validation of the sentinel lymph node hypothesis for breast carcinoma","volume":"226","author":"Turner","year":"1997","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00000658-199805000-00005","article-title":"Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer","volume":"227","author":"Cox","year":"1998","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/00000658-200105000-00012","article-title":"Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy: results of a multiinstitutional study","volume":"233","author":"McMasters","year":"2001","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib15","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1072-7515(01)00858-4","article-title":"Sentinel lymph node biopsy for breast cancer: impact of the number of sentinel nodes removed on the false-negative rate","volume":"192","author":"Wong","year":"2001","journal-title":"J Am Coll Surg"},{"key":"2024093006361329700_bib16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1072-7515(01)00798-0","article-title":"National practice patterns of sentinel lymph node dissection for breast carcinoma","volume":"192","author":"Lucci","year":"2001","journal-title":"J Am Coll Surg"},{"key":"2024093006361329700_bib17","first-page":"315","article-title":"The validity of the sentinel node concept in gastrointestinal cancers","volume":"101","author":"Kitagawa","year":"2000","journal-title":"Nippon Geka Gakkai Zasshi"},{"key":"2024093006361329700_bib18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1001\/archsurg.135.8.926","article-title":"Lymphatic mapping and focused analysis of sentinel lymph nodes upstage gastrointestinal neoplasms","volume":"135","author":"Tsioulias","year":"2000","journal-title":"Arch Surg"},{"key":"2024093006361329700_bib19","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1200\/JCO.2001.19.4.1128","article-title":"Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter phase II trial","volume":"19","author":"Bilchik","year":"2001","journal-title":"J Clin Oncol"},{"key":"2024093006361329700_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1067\/msy.2001.111699","article-title":"Application of sentinel node biopsy to gastric cancer surgery","volume":"129","author":"Hiratsuka","year":"2001","journal-title":"Surgery"},{"key":"2024093006361329700_bib21","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1046\/j.1365-2168.1998.00940.x","article-title":"Classification of adenocarcinoma of the oesophagogastric junction","volume":"85","author":"Siewert","year":"1998","journal-title":"Br J Surg"},{"key":"2024093006361329700_bib22","first-page":"121","volume-title":"Upper Gastrointestinal Surgery","author":"Griffin","year":"2001","edition":"2nd"},{"key":"2024093006361329700_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2168.1999.01043.x","article-title":"Transhiatal approach to total gastrectomy for adenocarcinoma of the gastric cardia","volume":"86","author":"Wayman","year":"1999","journal-title":"Br J Surg"},{"key":"2024093006361329700_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02468883","article-title":"The general rules for the gastric cancer study in surgery and pathology. Part I. Clinical classification","volume":"11","author":"Kajitani","year":"1981","journal-title":"Jpn J Surg"},{"key":"2024093006361329700_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02468890","article-title":"Guidelines for the clinical and pathologic studies for carcinoma of the esophagus","volume":"6","author":"Japanese Society for Esophageal Diseases","year":"1976","journal-title":"Jpn J Surg"},{"key":"2024093006361329700_bib26","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1002\/(SICI)1097-0142(19991215)86:12<2668::AID-CNCR11>3.0.CO;2-R","article-title":"International Union Against Cancer. Classification of isolated tumor cells and micrometastasis","volume":"86","author":"Hermanek","year":"1999","journal-title":"Cancer"},{"key":"2024093006361329700_bib27","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s002689900307","article-title":"Sentinel node biopsy in melanoma patients: dynamic lymphoscintigraphy followed by intraoperative gamma probe and vital dye guidance","volume":"21","author":"Pijpers","year":"1997","journal-title":"World J Surg"},{"key":"2024093006361329700_bib28","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1007\/PL00014793","article-title":"Radiopharmaceuticals in sentinel lymph-node detection\u2014an overview","volume":"26","author":"Wilhelm","year":"1999","journal-title":"Eur J Nucl Med"},{"key":"2024093006361329700_bib29","first-page":"145","article-title":"Lymph drainage originating from the lower esophagus and gastric cardia as measured by radioisotope uptake in the regional lymph nodes following lymphoscintigraphy","volume":"20","author":"Aikou","year":"1987","journal-title":"Lymphology"},{"key":"2024093006361329700_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF02471404","article-title":"Difference in main lymphatic pathways from the lower esophagus and gastric cardia","volume":"19","author":"Aikou","year":"1989","journal-title":"Jpn J Surg"},{"key":"2024093006361329700_bib31","first-page":"279","article-title":"The imaging of the sentinel nodes using lymphoscintigraphy in the patients with esophageal cancer","volume":"41","author":"Fujii","year":"2000","journal-title":"J Nucl Med"},{"key":"2024093006361329700_bib32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1010-7940(99)00122-0","article-title":"Three-field lymphadenectomy and pattern of lymph node spread in T3 adenocarcinoma of the distal esophagus and the gastro-esophageal junction","volume":"15","author":"van de Ven","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024093006361329700_bib33","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-5223(99)70377-6","article-title":"Node status in transmural esophageal adenocarcinoma and outcome after en bloc esophagectomy","volume":"117","author":"Nigro","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024093006361329700_bib34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/jjco\/28.6.378","article-title":"Clinicopathological characteristics of skipping lymph node metastases in patients with colorectal cancer","volume":"28","author":"Yamamoto","year":"1998","journal-title":"Jpn J Clin Oncol"},{"key":"2024093006361329700_bib35","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/BF02482311","article-title":"Lymphatic routes of the stomach demonstrated by gastric carcinomas with solitary lymph node metastasis","volume":"29","author":"Kosaka","year":"1999","journal-title":"Surg Today"},{"key":"2024093006361329700_bib36","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0039-6109(05)70256-5","article-title":"Pathologic analysis of the sentinel lymph node","volume":"80","author":"Treseler","year":"2000","journal-title":"Surg Clin North Am"},{"key":"2024093006361329700_bib37","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/1097-0142(20001101)89:9<1874::AID-CNCR2>3.0.CO;2-M","article-title":"Frequency and clinical impact of lymph node micrometastasis and tumor cell microinvolvement in patients with adenocarcinoma of the esophagogastric junction","volume":"89","author":"Mueller","year":"2000","journal-title":"Cancer"},{"key":"2024093006361329700_bib38","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2168.2000.01423.x","article-title":"Intraoperative sentinel lymph node examination by imprint cytology and frozen sectioning during breast surgery","volume":"87","author":"Motomura","year":"2000","journal-title":"Br J Surg"},{"key":"2024093006361329700_bib39","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2433::AID-CNCR18>3.0.CO;2-3","article-title":"Intraoperative examination of axillary sentinel lymph nodes in breast carcinoma patients","volume":"85","author":"Viale","year":"1999","journal-title":"Cancer"},{"key":"2024093006361329700_bib40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/bjs.4083","article-title":"Rapid immunohistochemical detection of lymph node micrometastasis during operation for upper gastrointestinal carcinoma","volume":"90","author":"Matsumoto","year":"2003","journal-title":"Br J Surg"},{"key":"2024093006361329700_bib41","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1365-2168.2002.02175.x","article-title":"Staging of oesophageal adenocarcinoma","volume":"89","author":"Hardwick","year":"2002","journal-title":"Br J Surg"},{"key":"2024093006361329700_bib42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00000658-200009000-00007","article-title":"Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical\/topographic classification in 1002 consecutive patients","volume":"232","author":"Siewert","year":"2000","journal-title":"Ann Surg"},{"key":"2024093006361329700_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1067\/msy.2001.110024","article-title":"The pattern of metastatic lymph node dissemination from adenocarcinoma of the esophagogastric junction","volume":"129","author":"Dresner","year":"2001","journal-title":"Surgery"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/92\/1\/60\/59442020\/bjs4693.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/92\/1\/60\/59442020\/bjs4693.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:37:57Z","timestamp":1727678277000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/92\/1\/60\/6144096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4693","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2005,1]]},"published":{"date-parts":[[2005,1,1]]}}}