{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:42:19Z","timestamp":1750653739366,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T00:00:00Z","timestamp":1094601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Altana Pharma, Zwanenburg, The Netherlands"},{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Arts and Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study assessed the long-term effect of Nissen fundoplication on oesophageal and oesophagogastric junction (OGJ) motility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Symptoms were scored and oesophageal manometry performed in 34 consecutive patients with chronic gastro-oesophageal reflux disease, before, 3 months after and 2 years after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Distal peristaltic amplitude increased from a median of 57 (95 per cent confidence interval (c.i.) 18 to 107) mmHg to 86 (95 per cent c.i. 54 to 208) mmHg (P &amp;lt; 0\u00b7001) at 3 months and 92 (45 to 210) mmHg (P &amp;lt; 0\u00b7001) at 2 years. In four patients the amplitude increased to more than 180 mmHg and three of these patients reported odynophagia. After surgery, a linear relationship was observed between the peristaltic amplitude and nadir OGJ relaxation pressure at 3 months (rs = 0\u00b768, P &amp;lt; 0\u00b7001) and 2 years (rs = 0\u00b764, P &amp;lt; 0\u00b7001). A significant correlation was also found between amplitude and both basal OGJ pressure and intrabolus pressure at 3 months (rs = 0\u00b758, P &amp;lt; 0\u00b7001 and rs = 0\u00b763, P &amp;lt; 0\u00b7001 respectively) and 2 years (rs = 0\u00b771, P &amp;lt; 0\u00b7001 and rs = 0\u00b749, P = 0\u00b7024). There was a relationship between peristaltic amplitude and the odynophagia score at 2 years (rs = 0\u00b760, P = 0\u00b7017).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Within 3 months of fundoplication the amplitude of oesophageal peristalsis increased substantially, leading to a nutcracker oesophagus and odynophagia in a subgroup of patients. These phenomena did not appear to progress with time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4759","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T08:29:04Z","timestamp":1095150544000},"page":"1466-1472","source":"Crossref","is-referenced-by-count":33,"title":["Long-term effect of fundoplication on motility of the oesophagus and oesophagogastric junction"],"prefix":"10.1093","volume":"91","author":[{"given":"R C H","family":"Scheffer","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Samsom","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T G","family":"Frakking","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J P M","family":"Smout","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H G","family":"Gooszen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The 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