{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:55:38Z","timestamp":1788324938394,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T00:00:00Z","timestamp":1106611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Clinical Key Projects of the Ministry of Health China","award":["321"],"award-info":[{"award-number":["321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to compare the outcome after simultaneous hepatectomy and splenectomy with that after hepatectomy alone for hepatocellular carcinoma with associated hypersplenism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two hundred and four patients with hepatocellular carcinoma and cirrhotic hypersplenism were divided non-randomly into two groups. Ninety-four underwent simultaneous hepatectomy and splenectomy and 110 underwent hepatectomy alone. White blood cell (WBC) and platelet counts, total serum bilirubin levels, immune function, incidence of complications and 5-year survival rates in the two groups were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>WBC and platelet counts, distribution of T cell subsets, and levels of bilirubin, interferon \u03b3 and interleukin 2 were different between the two groups after operation. All patients who underwent hepatectomy and splenectomy but only 15\u00b75 per cent of those who had hepatectomy alone completed adjuvant chemotherapy. The 5-year tumour-free survival rate was significantly higher after hepatectomy and splenectomy than after hepatectomy alone (37 versus 27\u00b73 per cent; P = 0\u00b7003), although overall survival rates were similar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Simultaneous hepatectomy and splenectomy was associated with improved 5-year tumour-free survival in patients with hepatocellular carcinoma and hypersplenism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4776","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T18:46:34Z","timestamp":1106678794000},"page":"334-339","source":"Crossref","is-referenced-by-count":87,"title":["Use of hepatectomy and splenectomy to treat hepatocellular carcinoma with cirrhotic hypersplenism"],"prefix":"10.1093","volume":"92","author":[{"given":"X-P","family":"Chen","sequence":"first","affiliation":[{"name":"Hepatic Surgery Centre, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z-D","family":"Wu","sequence":"additional","affiliation":[{"name":"Hepatic Surgery Centre, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z-Y","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatic Surgery Centre, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F-Z","family":"Qiu","sequence":"additional","affiliation":[{"name":"Hepatic Surgery Centre, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,1,25]]},"reference":[{"key":"2021070906085981400_bib1","first-page":"518","article-title":"A study on Th1\/Th2 cytokines immunological condition in the patients with primary hepatocellular carcinoma combined with liver cirrhosis","volume":"18","author":"Cao","year":"2001","journal-title":"Chin J Exp Surg"},{"key":"2021070906085981400_bib2","first-page":"389","article-title":"Management of hepatocellular carcinoma","volume":"47","author":"Lau","year":"2002","journal-title":"J R Coll Surg Edinb"},{"key":"2021070906085981400_bib3","first-page":"1423","volume-title":"Surgery of the Liver and Biliary Tract","author":"Lau","year":"2000","edition":"3rd"},{"key":"2021070906085981400_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/1097-0142(19890715)64:2<536::AID-CNCR2820640230>3.0.CO;2-X","article-title":"Surgery of small hepatocellular carcinoma. 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