{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:32:54Z","timestamp":1763746374252},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T00:00:00Z","timestamp":1098662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Many studies have analysed prognostic factors following oesophagectomy, but few have examined survival determinants in node-negative (N0) oesophageal cancer. The prognostic significance of a number of histological variables following surgical resection of N0 oesophageal cancer was studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The case notes of 219 patients undergoing potentially curative oesophagectomy for N0 squamous cell carcinoma or adenocarcinoma of the oesophagus were reviewed. Details of the patient's sex, age at operation, histological type, longitudinal tumour length, tumour (T) stage, circumferential resection margin involvement, tumour grade, presence of vascular invasion, perineural invasion, Barrett's metaplasia, and survival were noted. Univariate and multivariate analyses were performed to identify prognostic factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Univariate analysis revealed three factors that correlated with poor prognosis: T stage (P = 0\u00b7024), adenocarcinoma (P = 0\u00b7033) and degree of differentiation (P = 0\u00b7001). Multivariate analysis revealed that all three were significant independent adverse prognostic indicators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Surgical resection of node-negative oesophageal cancer is associated with diverse long-term outcomes. This diversity of outcome is not reflected in the tumour node metastasis (TNM)-based staging system. The utility of the TNM system in predicting prognosis after surgical resection is open to question.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4778","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T20:55:59Z","timestamp":1100292959000},"page":"1586-1591","source":"Crossref","is-referenced-by-count":45,"title":["Pathological determinants of survival in node-negative oesophageal cancer"],"prefix":"10.1093","volume":"91","author":[{"given":"O A","family":"Khan","sequence":"first","affiliation":[{"name":"Thoracic Unit, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Thoracic Unit, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Soomro","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Duffy","sequence":"additional","affiliation":[{"name":"Thoracic Unit, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W E","family":"Morgan","sequence":"additional","affiliation":[{"name":"Thoracic Unit, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F D","family":"Beggs","sequence":"additional","affiliation":[{"name":"Thoracic Unit, Nottingham City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,10,25]]},"reference":[{"key":"2021070907195858600_bib1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2","article-title":"Changing patterns in the incidence of esophagus and gastric carcinoma in the United States","volume":"83","author":"Devesa","year":"1998","journal-title":"Cancer"},{"key":"2021070907195858600_bib2","first-page":"295","article-title":"Results of surgical treatment of oesophageal cancer","volume":"41","author":"Sabanathan","year":"1996","journal-title":"J R Coll Surg Edinb"},{"key":"2021070907195858600_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1055-3207(18)30213-8","article-title":"Standard resection for cancer of the esophagus and cardia","volume":"8","author":"Ellis","year":"1999","journal-title":"Surg Oncol Clin N Am"},{"key":"2021070907195858600_bib4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-5223(98)70159-X","article-title":"Surgery for esophageal cancer in elderly patients: the view from Nottingham","volume":"116","author":"Alexiou","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021070907195858600_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1055-3207(18)30315-6","article-title":"Prognostic factors in esophageal cancer","volume":"6","author":"Patti","year":"1997","journal-title":"Surg Oncol Clin N Am"},{"key":"2021070907195858600_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/bjc.1989.87","article-title":"Squamous carcinoma of the oesophagus: histological criteria and their prognostic significance","volume":"59","author":"Edwards","year":"1989","journal-title":"Br J Cancer"},{"key":"2021070907195858600_bib7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.bjc.6990499","article-title":"Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biology","volume":"80","author":"Shimada","year":"1999","journal-title":"Br J Cancer"},{"key":"2021070907195858600_bib8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/1097-0142(19910701)68:1<142::AID-CNCR2820680126>3.0.CO;2-X","article-title":"Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer","volume":"68","author":"Mukaida","year":"1991","journal-title":"Cancer"},{"key":"2021070907195858600_bib9","first-page":"389","article-title":"Prognostic factors in node-negative squamous cell carcinoma of the thoracic esophagus","volume":"1","author":"Tachibana","year":"2000","journal-title":"Int J Surg Investig"},{"key":"2021070907195858600_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000064417","article-title":"Prognosis of patients with T2 N0 tumors in the alimentary tract: should they be considered as early cancers?","volume":"66","author":"Tachibana","year":"2002","journal-title":"Digestion"},{"key":"2021070907195858600_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3835(00)00374-8","article-title":"Clinical significance of lymph node micrometastasis of pN0 esophageal squamous cell carcinoma","volume":"153","author":"Matsumoto","year":"2000","journal-title":"Cancer Lett"},{"key":"2021070907195858600_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jso.10080","article-title":"Clinical implications of lymph node micrometastasis in patients with histologically node-negative (pN0) esophageal carcinoma","volume":"79","author":"Nakamura","year":"2002","journal-title":"J Surg Oncol"},{"key":"2021070907195858600_bib13","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin","year":"1999","edition":"5th"},{"key":"2021070907195858600_bib14","volume-title":"Histological Typing of Gastric and Oesophageal Tumours","author":"Ota","year":"1977"},{"key":"2021070907195858600_bib15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0022-5223(98)70332-0","article-title":"Proposed revision of the staging classification for esophageal cancer","volume":"115","author":"Korst","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021070907195858600_bib16","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0003-4975(02)03508-7","article-title":"The influence of perioperative blood transfusion on survival after esophageal resection for carcinoma","volume":"73","author":"Langley","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2021070907195858600_bib17","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1067\/mtc.2003.170","article-title":"Refining esophageal cancer staging","volume":"125","author":"Rice","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021070907195858600_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00000658-200109000-00010","article-title":"Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1000 consecutive resections at a single center in the Western world","volume":"234","author":"Siewert","year":"2001","journal-title":"Ann Surg"},{"key":"2021070907195858600_bib19","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/ajcp\/95.6.844","article-title":"Prognostic factors in esophageal squamous carcinoma. A study of histologic features, blood group expression, and DNA ploidy","volume":"95","author":"Robey-Cafferty","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"2021070907195858600_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/gut.48.5.667","article-title":"Circumferential resection margin involvement: an independent predictor of survival following surgery for oesophageal cancer","volume":"48","author":"Dexter","year":"2001","journal-title":"Gut"},{"key":"2021070907195858600_bib21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<769::AID-CNCR3>3.0.CO;2-I","article-title":"The prognostic significance of lymph node micrometastasis in patients with esophageal carcinoma","volume":"85","author":"Glickman","year":"1999","journal-title":"Cancer"},{"key":"2021070907195858600_bib22","volume-title":"American Joint Committee on Cancer. AJCC Cancer Staging Handbook","author":"Greene","year":"2002","edition":"6th"},{"key":"2021070907195858600_bib23","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0022-5223(96)70367-7","article-title":"Stage II esophageal carcinoma: the significance of T and N","volume":"111","author":"Killinger","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021070907195858600_bib24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/sj.bjc.6600931","article-title":"Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer","volume":"88","author":"Khan","year":"2003","journal-title":"Br J Cancer"},{"key":"2021070907195858600_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1442-2050.2002.00230.x","article-title":"Multivariate analysis of clinical, operative and pathologic features of esophageal cancer: who needs adjuvant therapy?","volume":"15","author":"Zafirellis","year":"2002","journal-title":"Dis Esophagus"},{"key":"2021070907195858600_bib26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s005950050245","article-title":"An evaluation of neural invasion in esophageal cancer","volume":"28","author":"Tanaka","year":"1998","journal-title":"Surg Today"},{"key":"2021070907195858600_bib27","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/cncr.10868","article-title":"Prognostic factors for the survival of patients with esophageal carcinoma in the US: the importance of tumor length and lymph node status","volume":"95","author":"Eloubeidi","year":"2002","journal-title":"Cancer"},{"key":"2021070907195858600_bib28","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0140-6736(02)08651-8","article-title":"Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial","volume":"359","author":"Medical Research Council Oesophageal Cancer Working Party","year":"2002","journal-title":"Lancet"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4778","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/12\/1586\/36728826\/bjs4778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/91\/12\/1586\/36728826\/bjs4778.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T16:56:57Z","timestamp":1625849817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/91\/12\/1586\/6151084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,25]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2004,10,25]]},"published-print":{"date-parts":[[2004,11,17]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4778","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,12]]},"published":{"date-parts":[[2004,10,25]]}}}