{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:41:38Z","timestamp":1785840098519,"version":"3.56.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T00:00:00Z","timestamp":1107129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Minimally invasive parathyroidectomy (MIP) has been introduced for the treatment of patients with primary hyperparathyroidism (pHPT). Thus far, only one randomized trial has compared video-assisted MIP with conventional bilateral cervical exploration (BCE). The value of open MIP is therefore not known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifty patients with a solitary parathyroid adenoma localized before surgery by sestamibi scintigraphy were randomized to undergo BCE under general anaesthesia (n = 25) or targeted MIP via a 2-cm incision using local anaesthesia (n = 25). Postoperative hypocalcaemia was the primary endpoint. Secondary outcome measures were operating time, complications, postoperative analgesia and recurrent disease. Follow-up was carried out at 1 and 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All patients who underwent BCE and 24 of those who had MIP were cured by the primary operation. Operating time was 22 min shorter in the MIP group (P = 0\u00b7024). Serum levels of calcium were slightly lower during the first 4 days after surgery in the BCE group (P = 0\u00b7022). No other no significant differences were found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Targeted MIP using local anaesthesia reduces operating time and causes less postoperative biochemical hypocalcaemia compared with bilateral neck exploration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4814","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T11:48:53Z","timestamp":1101901733000},"page":"190-197","source":"Crossref","is-referenced-by-count":119,"title":["Conventional bilateral cervical exploration <i>versus<\/i> open minimally invasive parathyroidectomy under local anaesthesia for primary hyperparathyroidism"],"prefix":"10.1093","volume":"92","author":[{"given":"A","family":"Bergenfelz","sequence":"first","affiliation":[{"name":"Department of Surgery, Philipps-University Marburg , Baldingerstrasse, D-35033 Marburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kanngiesser","sequence":"additional","affiliation":[{"name":"Department of Surgery, Philipps-University Marburg , Baldingerstrasse, D-35033 Marburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Zielke","sequence":"additional","affiliation":[{"name":"Department of Surgery, Philipps-University Marburg , Baldingerstrasse, D-35033 Marburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Nies","sequence":"additional","affiliation":[{"name":"Department of Surgery, Philipps-University Marburg , Baldingerstrasse, D-35033 Marburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rothmund","sequence":"additional","affiliation":[{"name":"Department of Surgery, Philipps-University Marburg , Baldingerstrasse, D-35033 Marburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2024093006495811500_bib1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/BF01665301","article-title":"Surgical treatment of primary hyperparathyroidism: an institutional perspective","volume":"15","author":"van Heerden","year":"1991","journal-title":"World J Surg"},{"key":"2024093006495811500_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00000658-198203000-00001","article-title":"Unilateral parathyroidectomy in hyperparathyroidism due to single adenoma","volume":"195","author":"Tibblin","year":"1982","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00000658-200211000-00001","article-title":"Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial","volume":"236","author":"Bergenfelz","year":"2002","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s004649900634","article-title":"Endoscopic endocrine surgery in the neck. An initial report of endoscopic subtotal parathyroidectomy","volume":"12","author":"Naitoh","year":"1998","journal-title":"Surg Endosc"},{"key":"2024093006495811500_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/bjs.4183","article-title":"Limits and drawbacks of video-assisted parathyroidectomy","volume":"90","author":"Berti","year":"2003","journal-title":"Br J Surg"},{"key":"2024093006495811500_bib6","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1067\/msy.2099.101433","article-title":"Outpatient minimally invasive parathyroidectomy: a combination of sestamibi-SPECT localization, cervical block anesthesia, and intraoperative parathyroid hormone assay","volume":"126","author":"Chen","year":"1999","journal-title":"Surgery"},{"key":"2024093006495811500_bib7","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/01.SLA.0000064362.58751.59","article-title":"Sestamibi scanning and minimally invasive radioguided parathyroidectomy without intraoperative parathyroid hormone measurement","volume":"237","author":"Goldstein","year":"2003","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1067\/msy.2001.119112","article-title":"Indications and results of video-assisted parathyroidectomy by a lateral approach in patients with primary hyperparathyroidism","volume":"130","author":"Henry","year":"2001","journal-title":"Surgery"},{"key":"2024093006495811500_bib9","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1067\/msy.2099.101834","article-title":"Unilateral neck exploration under local anesthesia: the approach of choice for asymptomatic primary hyperparathyroidism","volume":"126","author":"Inabnet","year":"1999","journal-title":"Surgery"},{"key":"2024093006495811500_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archsurg.135.4.481","article-title":"Minimally invasive surgery for primary hyperparathyroidism: systematic review","volume":"135","author":"Reeve","year":"2000","journal-title":"Arch Surg"},{"key":"2024093006495811500_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00000658-200004000-00016","article-title":"Direct, minimally invasive adenomectomy for primary hyperparathyroidism. An alternative to conventional neck exploration?","volume":"231","author":"Smit","year":"2000","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00000658-200205000-00008","article-title":"Six hundred fifty-six consecutive explorations for primary hyperparathyroidism","volume":"235","author":"Udelsman","year":"2002","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1445-2197.2002.02310.x","article-title":"Minimally invasive parathyroidectomy using the \u2018focused\u2019 lateral approach. I. Results of the first 100 consecutive cases","volume":"72","author":"Agarwal","year":"2002","journal-title":"ANZ J Surg"},{"key":"2024093006495811500_bib14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1067\/msy.2002.123853","article-title":"Minimally invasive parathyroid surgery in 103 patients with local\/regional anesthesia, without exclusion criteria","volume":"131","author":"Monchik","year":"2002","journal-title":"Surgery"},{"key":"2024093006495811500_bib15","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1067\/msy.2099.101425","article-title":"Bilateral neck exploration for parathyroidectomy under local anesthesia: a viable technique for patients with coexisting thyroid disease with or without sestamibi scanning","volume":"126","author":"LoGerfo","year":"1999","journal-title":"Surgery"},{"key":"2024093006495811500_bib16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/BF02067323","article-title":"Parathyroid adenomectomy under local anesthesia with intra-operative monitoring of UcAMP and\/or 1\u201384 PTH","volume":"16","author":"Chapuis","year":"1992","journal-title":"World J Surg"},{"key":"2024093006495811500_bib17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1067\/msy.2099.102269","article-title":"Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism: a prospective randomized study","volume":"126","author":"Miccoli","year":"1999","journal-title":"Surgery"},{"key":"2024093006495811500_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1067\/msy.2000.107977","article-title":"Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism","volume":"128","author":"Ng","year":"2000","journal-title":"Surgery"},{"key":"2024093006495811500_bib19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/00000658-199405000-00015","article-title":"A new approach to parathyroidectomy","volume":"219","author":"Irvin","year":"1994","journal-title":"Ann Surg"},{"key":"2024093006495811500_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF00206562","article-title":"Intraoperative monitoring of intact PTH during surgery for primary hyperparathyroidism","volume":"379","author":"Bergenfelz","year":"1994","journal-title":"Langenbecks Arch Chir"},{"key":"2024093006495811500_bib21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/BF01665303","article-title":"The role of the pathologist in diagnosis and surgical decision making in hyperparathyroidism","volume":"15","author":"Grimelius","year":"1991","journal-title":"World J Surg"},{"key":"2024093006495811500_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/bjs.1800790926","article-title":"Surgery for primary hyperparathyroidism performed under local anaesthesia","volume":"79","author":"Bergenfelz","year":"1992","journal-title":"Br J Surg"},{"key":"2024093006495811500_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/archsurg.135.2.142","article-title":"Risk factors for postoperative hypocalcemia after surgery for primary hyperparathyroidism","volume":"135","author":"Westerdahl","year":"2000","journal-title":"Arch Surg"},{"key":"2024093006495811500_bib24","first-page":"1343","article-title":"Therapeutischer Versuch bei Osteitis fibrosa generalisata mittels Exstirpation eines Epitelk\u00f6rperchentumors","volume":"50","author":"Mandl","year":"1925","journal-title":"Wien Klin Wochenschr"},{"key":"2024093006495811500_bib25","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/archsurg.1988.01400290100017","article-title":"Parathyroid exploration with local anesthesia in elderly and high-risk patients","volume":"123","author":"Pyrtek","year":"1988","journal-title":"Arch Surg"},{"key":"2024093006495811500_bib26","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0039-6060(97)90046-5","article-title":"Sestamibi versus thallium subtraction scintigraphy in parathyroid localization: a prospective comparative study in patients with predominantly mild hyperparathyroidism","volume":"121","author":"Bergenfelz","year":"1997","journal-title":"Surgery"},{"key":"2024093006495811500_bib27","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/jc.2002-021095","article-title":"The impact of sestamibi scanning on the outcome of parathyroid surgery","volume":"88","author":"Allendorf","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2024093006495811500_bib28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archsurg.137.8.896","article-title":"Multiple-gland disease in primary hyperparathyroidism: a function of operative approach?","volume":"137","author":"Lee","year":"2002","journal-title":"Arch Surg"},{"key":"2024093006495811500_bib29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1072-7515(03)00108-X","article-title":"Differing histologic findings after bilateral and focused parathyroidectomy","volume":"196","author":"Genc","year":"2003","journal-title":"J Am Coll Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/92\/2\/190\/59443370\/bjs4814.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/92\/2\/190\/59443370\/bjs4814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:04:12Z","timestamp":1727679852000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/92\/2\/190\/6144097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,31]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,1]]},"published-print":{"date-parts":[[2005,1,31]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4814","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,2]]},"published":{"date-parts":[[2005,1,31]]}}}