{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:03:15Z","timestamp":1792839795325,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T00:00:00Z","timestamp":1112140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It is not known whether pylorus-preserving duodenopancreatectomy is as effective as the classical Whipple procedure in the resection of pancreatic and periampullary tumours. A prospective randomized trial was undertaken to compare the results of the two procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical data, histological findings, short-term results, survival and quality of life of all patients having surgery for suspected pancreatic or periampullary cancer between June 1996 and September 2001 were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred and fourteen patients were randomized to undergo either a standard or a pylorus-preserving Whipple resection. After exclusion of 84 patients on the basis of intraoperative findings, 130 patients (66 standard Whipple operation and 64 pylorus-preserving resection) were entered into the trial. Of these, 110 patients with proven adenocarcinoma (57 standard Whipple and 53 pylorus-preserving resection) were analysed for long-term survival and quality of life. There was no difference in perioperative morbidity. Long-term survival, quality of life and weight gain were identical after a median follow-up of 63\u00b71 (range 4\u201393) months. At 6 months, capacity to work was better after the pylorus-preserving procedure (77 versus 56 per cent; P = 0\u00b7019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Both procedures were equally effective for the treatment of pancreatic and periampullary cancer. Pylorus-preserving Whipple resection offers some minor advantages in the early postoperative period, but not in the long term.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4881","type":"journal-article","created":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T16:47:20Z","timestamp":1112201240000},"page":"547-556","source":"Crossref","is-referenced-by-count":225,"title":["Randomized clinical trial of pylorus-preserving duodenopancreatectomy <i>versus<\/i> classical Whipple resection\u2014long term results"],"prefix":"10.1093","volume":"92","author":[{"given":"C A","family":"Seiler","sequence":"first","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Schmied","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Friess","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"2021070906093325100_bib1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00000658-199709000-00004","article-title":"Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes","volume":"226","author":"Yeo","year":"1997","journal-title":"Ann Surg"},{"key":"2021070906093325100_bib2","first-page":"42","article-title":"Onkologische Standardchirurgie des Pankreaskarzinoms","volume":"14","author":"Baer","year":"1998","journal-title":"Chirurgische Gastroenterologie"},{"key":"2021070906093325100_bib3","first-page":"246","article-title":"Chirurgische Ergebnisse und Indikation zu adjuvanten Massnahmen beim Pankreascarcinom","volume":"65","author":"Beger","year":"1994","journal-title":"Chirurg"},{"key":"2021070906093325100_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/bjs.1800830512","article-title":"Survival after resection for ductal adenocarcinoma of the pancreas","volume":"83","author":"Sperti","year":"1996","journal-title":"Br J Surg"},{"key":"2021070906093325100_bib5","first-page":"439","article-title":"Das Carcinom der Papilla duodeni und seine radikale Entfernung","volume":"78","author":"Kausch","year":"1912","journal-title":"Beitr Klin Chir"},{"key":"2021070906093325100_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1056\/NEJM194203262261303","article-title":"Present day surgery of the pancreas","volume":"226","author":"Whipple","year":"1942","journal-title":"N Engl J Med"},{"key":"2021070906093325100_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/bjs.18003112406","article-title":"Carcinoma of the ampulla of Vater. 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