{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:26:32Z","timestamp":1788870392590,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T00:00:00Z","timestamp":1116201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ethicon Endosurgery"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Both laparoscopic Nissen fundoplication (LNF) and proton-pump inhibitor (PPI) therapy are established in the treatment of gastro-oesophageal reflux disease (GORD). The aim of this study was to compare these two treatments in a randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between July 1997 and August 2001, 340 patients with a history of GORD for at least 6 months were investigated by endoscopy, 24-h pH monitoring and manometry. Of these, 217 were randomized, 109 to LNF and 108 to PPI therapy. The two groups were well matched for age, sex, weight and severity of reflux. Twenty-four-hour pH monitoring and manometry were performed 3 months after treatment, and quality of life was assessed in both groups using the Psychological General Well-being Index and the Gastrointestinal Symptom Rating Scale at 3 and 12 months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 3 months there was an improvement in lower oesophageal sphincter pressure from 6\u00b73 to 17\u00b72 mmHg in the LNF group but no change in the PPI group (8\u00b71 and 7\u00b79 mmHg before and after treatment respectively) (P &amp;lt; 0\u00b7001). The mean DeMeester acid exposure score improved from 42\u00b77 to 8\u00b76 (P &amp;lt; 0\u00b7001) in the LNF group and from 36\u00b79 to 17\u00b77 in the PPI group (P &amp;lt; 0\u00b7001). The mean gastrointestinal symptom and general well-being scores improved from 31\u00b77 and 95\u00b74 respectively before treatment to 37\u00b70 and 106\u00b72 at 12 months after LNF, compared with changes from 34\u00b73 and 98\u00b75 to 35\u00b70 and 100\u00b74 respectively in the PPI group. The differences in both of these scores were significant between the two groups at 12 months (P = 0\u00b7003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LNF leads to significantly less acid exposure of the lower oesophagus at 3 months and significantly greater improvements in both gastrointestinal and general well-being after 12 months compared with PPI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.4934","type":"journal-article","created":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T12:47:15Z","timestamp":1116247635000},"page":"695-699","source":"Crossref","is-referenced-by-count":140,"title":["Randomized clinical trial of laparoscopic Nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux"],"prefix":"10.1093","volume":"92","author":[{"given":"D","family":"Mahon","sequence":"first","affiliation":[{"name":"Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Decadt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hindmarsh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lowndes","sequence":"additional","affiliation":[{"name":"Physiology Laboratory, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Beckingham","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Newcombe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"2021070906140077400_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.38.4.481","article-title":"Natural history of reflux oesophagitis: a 10 year follow up of its effect on patient symptomatology and quality of life","volume":"38","author":"McDougall","year":"1996","journal-title":"Gut"},{"key":"2021070906140077400_bib2","first-page":"186","article-title":"Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)","volume":"12","author":"Guidelines for surgical treatment of gastroesophageal reflux disease (GERD)","year":"1998","journal-title":"Surg Endosc"},{"key":"2021070906140077400_bib3","first-page":"138","article-title":"Laparoscopic Nissen fundoplication: preliminary report","volume":"1","author":"Dallemagne","year":"1991","journal-title":"Surg Laparosc Endosc"},{"key":"2021070906140077400_bib4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/gut.38.4.487","article-title":"Laparoscopic Nissen fundoplication\u2014200 consecutive cases","volume":"38","author":"Gotley","year":"1996","journal-title":"Gut"},{"key":"2021070906140077400_bib5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1046\/j.1365-2168.2000.01634.x","article-title":"Chronic dysphagia following laparoscopic fundoplication","volume":"87","author":"Bessell","year":"2000","journal-title":"Br J Surg"},{"key":"2021070906140077400_bib6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00464-001-9103-9","article-title":"Long-term results of antireflux surgery","volume":"16","author":"Granderath","year":"2002","journal-title":"Surg Endosc"},{"key":"2021070906140077400_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1091-255X(01)80012-3","article-title":"Five- to eight-year outcome of the first laparoscopic Nissen fundoplications","volume":"5","author":"Bammer","year":"2001","journal-title":"J Gastrointest Surg"},{"key":"2021070906140077400_bib8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM197508072930602","article-title":"Medical and surgical management of reflux esophagitis. 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