{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:31:25Z","timestamp":1773268285901,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T00:00:00Z","timestamp":1115856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with early gastric cancer may be treated by minimally invasive surgery. This study investigated the value of sentinel node (SN) navigation surgery, including detection of micrometastases, in patients with clinical (c) T1 and T2 gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The day before surgery 99mTc-radiolabelled tin colloid was injected submucosally near the tumour. After resecting the stomach, radioisotope uptake in all dissected lymph nodes was measured during and after surgery. Micrometastasis was detected immunohistochemically using an anticytokeratin antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SNs were identified in 99 of 104 patients. The rate of identification of SNs in patients with cT1 and cT2 tumours, excluding three technical failures, was 99 and 95 per cent respectively. Lymph node metastases and\/or micrometastases were found in 28 patients (15 cT1 and 13 cT2). In the 15 patients with cT1 tumours, at least one SN contained metastasis and\/or micrometastasis. For cT1 tumours, the sensitivity and accuracy of detecting SNs were both 100 per cent. Six patients with cT2 tumours had false-negative results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SN navigation surgery appears to be clinically useful only for cT1 tumours. Based on SN results, the extent of lymphadenectomy may be reduced in patients with early gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.4953","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T15:46:59Z","timestamp":1115912819000},"page":"886-889","source":"Crossref","is-referenced-by-count":52,"title":["Detection of sentinel nodes and micrometastases using radioisotope navigation and immunohistochemistry in patients with gastric cancer"],"prefix":"10.1093","volume":"92","author":[{"given":"Y","family":"Uenosono","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Natsugoe","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ehi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Arigami","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hokita","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Aikou","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,5,12]]},"reference":[{"key":"2021070906133226900_bib1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/archsurg.1992.01420040034005","article-title":"Technical details of intraoperative lymphatic mapping for early stage melanoma","volume":"127","author":"Morton","year":"1992","journal-title":"Arch Surg"},{"key":"2021070906133226900_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s004230050185","article-title":"Can sentinel node biopsy indicate rational extent of lymphadenectomy in gastric cancer surgery? Fundamental and new information on lymph-node dissection","volume":"384","author":"Maruyama","year":"1999","journal-title":"Langenbecks Arch Surg"},{"key":"2021070906133226900_bib3","first-page":"90S","article-title":"Can sentinel node navigation surgery reduce the extent of lymph node dissection in gastric cancer?","volume":"8","author":"Aikou","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"2021070906133226900_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/PL00011681","article-title":"Japanese Classification of Gastric Carcinoma","volume":"1","author":"Japanese Gastric Cancer Association","year":"1998","journal-title":"Gastric Cancer"},{"key":"2021070906133226900_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1083\/jcb.95.2.580","article-title":"Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies","volume":"95","author":"Woodcock Mitchell","year":"1982","journal-title":"J Cell Biol"},{"key":"2021070906133226900_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/ajcp\/88.3.297","article-title":"Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5\u00b72","volume":"88","author":"Listrom","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"2021070906133226900_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/32.2.6198355","article-title":"Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)","volume":"32","author":"Cordell","year":"1984","journal-title":"J Histochem Cytochem"},{"key":"2021070906133226900_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/01.sla.0000086543.45557.cb","article-title":"Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases","volume":"238","author":"Morton","year":"2003","journal-title":"Ann Surg"},{"key":"2021070906133226900_bib9","first-page":"86S","article-title":"Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: a novel and minimally invasive approach","volume":"8","author":"Kitagawa","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"2021070906133226900_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1072-7515(02)01594-6","article-title":"Sentinel lymph node mapping for gastric cancer using a dual procedure with dye- and gamma probe-guided techniques","volume":"196","author":"Hayashi","year":"2003","journal-title":"J Am Coll Surg"},{"key":"2021070906133226900_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00104-002-0604-4","article-title":"Lymphatic mapping and sentinel lymph node biopsy in gastric cancer","volume":"74","author":"Gretschel","year":"2003","journal-title":"Chirurg"},{"key":"2021070906133226900_bib12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/000313480206801101","article-title":"Lymphatic mapping for gastric adenocarcinoma","volume":"68","author":"Hundley","year":"2002","journal-title":"Am Surg"},{"key":"2021070906133226900_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00268-001-0226-x","article-title":"Sentinel node concept in gastric carcinoma","volume":"26","author":"Ichikura","year":"2002","journal-title":"World J Surg"},{"key":"2021070906133226900_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/bjs.4031","article-title":"Mapping sentinel nodes in patients with early-stage gastric carcinoma","volume":"90","author":"Miwa","year":"2003","journal-title":"Br J Surg"},{"key":"2021070906133226900_bib15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1046\/j.1365-2168.2002.02065.x","article-title":"Radio-guided sentinel node detection for gastric cancer","volume":"89","author":"Kitagawa","year":"2002","journal-title":"Br J Surg"},{"key":"2021070906133226900_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0304-3835(03)00389-6","article-title":"Evaluation of colloid size for sentinel nodes detection using radioisotope in early gastric cancer","volume":"200","author":"Uenosono","year":"2003","journal-title":"Cancer Lett"},{"key":"2021070906133226900_bib17","first-page":"317","article-title":"The concept of lymph node micrometastasis for sentinel node navigation surgery","volume":"55","author":"Natsugoe","year":"2000","journal-title":"Rinshogeka (in Japanese)"},{"key":"2021070906133226900_bib18","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/(SICI)1097-0142(19970315)79:6<1069::AID-CNCR3>3.0.CO;2-B","article-title":"Immunohistochemical evaluation of lymph node micrometastases from gastric carcinomas","volume":"79","author":"Ishida","year":"1997","journal-title":"Cancer"},{"key":"2021070906133226900_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/1097-0142(20010815)92:4<753::AID-CNCR1379>3.0.CO;2-5","article-title":"Immunohistochemically detected micrometastases of the lymph nodes in patients with gastric carcinoma","volume":"92","author":"Fukagawa","year":"2001","journal-title":"Cancer"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.4953","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/7\/886\/36731706\/bjs4953.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/7\/886\/36731706\/bjs4953.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T22:12:36Z","timestamp":1706220756000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/92\/7\/886\/6144259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,12]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2005,5,12]]},"published-print":{"date-parts":[[2005,6,16]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.4953","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,7]]},"published":{"date-parts":[[2005,5,12]]}}}