{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:29:50Z","timestamp":1764052190974},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T00:00:00Z","timestamp":1120435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Dutch Organization for Scientific Research","award":["907-00-033"],"award-info":[{"award-number":["907-00-033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sacral neuromodulation (SNM) is a new treatment for faecal incontinence. At present the exact underlying mechanism is still unclear. Modulation of the sacral reflex arcs might have an effect on rectal sensitivity, wall tension and compliance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fifteen consecutive patients with faecal incontinence who qualified for SNM underwent barostat measurements before and during neuromodulation. An \u2018infinitely\u2019 compliant plastic bag with a volume of 600 ml was placed in the rectum and connected to a computer-controlled barostat system. An isobaric phasic distension protocol was used. Patients were asked to report rectal filling sensations: first sensation (FS), earliest urge to defaecate (EUD) and an irresistible, painful urge to defaecate (maximum tolerated volume; MTV). Rectal wall tension and compliance were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During isobaric phasic distension each patient experienced all rectal filling sensations at the time of stimulation. Median volume thresholds decreased significantly during stimulation, from 98\u00b71 to 44\u00b72 ml for FS (P = 0\u00b7003), from 132\u00b73 to 82\u00b78 ml for EUD (P = 0\u00b7001) and from 205\u00b78 to 162\u00b78 ml for MTV (P = 0\u00b7002). Pressure thresholds tended to be lower for all filling sensations, but only that to evoke MTV was reduced significantly by stimulation (37\u00b73 versus 30\u00b73 mmHg; P = 0\u00b7005). Median rectal wall tension for all filling sensations decreased significantly with stimulation. There was no significant difference between compliance before and during stimulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SNM affects rectal sensory perception, but further research is required to clarify the mechanism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4977","type":"journal-article","created":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T15:33:30Z","timestamp":1120491210000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":60,"title":["Effect of sacral neuromodulation on the rectum"],"prefix":"10.1093","volume":"92","author":[{"given":"\u00d6","family":"Uluda\u01e7","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G 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