{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:38:47Z","timestamp":1791848327434,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2005,7,25]],"date-time":"2005-07-25T00:00:00Z","timestamp":1122249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3233B0-103182"],"award-info":[{"award-number":["3233B0-103182"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3200B0-103183"],"award-info":[{"award-number":["3200B0-103183"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Alveolar echinococcosis is a rare disorder, which makes a comparison of different treatment modalities within a clinical trial difficult to perform. Data prospectively recorded over a period of 25 years were used to evaluate three therapeutic strategies: benzimidazole therapy alone, complete \u2018curative\u2019 resection followed by 2 years of adjuvant benzimidazole treatment, and partial debulking resection followed by continuous administration of a benzimidazole.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Details of 113 patients with hepatic alveolar echinococcosis treated between 1976 and 2003 were analysed. Kaplan\u2013Meier survival curves were constructed and, using a Cox regression model, patient age, year of initial treatment and PNM stage were entered as co-variates in the analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Kaplan\u2013Meier overall survival curves stratified for treatment strategy indicated an improved long-term survival in patients undergoing the debulking procedure (P = 0\u00b7061) or curative resection (P = 0\u00b7002) compared with benzimidazole therapy alone. However, when PNM stage, patient age and year of initial treatment were introduced into the analysis, there was a trend for survival advantage only with curative resection (P = 0\u00b707 versus benzimidazole alone). Debulking resulted in a higher rate of progression of hepatic echinococcosis than curative surgery (P = 0\u00b7008). The incidence of parasite-related complications was similar for debulking resection and benzimidazole therapy alone (P = 0\u00b7706).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Debulking hepatic resections do not appear to offer any advantage in the treatment of patients with alveolar echinococcosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.4998","type":"journal-article","created":{"date-parts":[[2005,7,25]],"date-time":"2005-07-25T16:47:39Z","timestamp":1122310059000},"page":"1110-1116","source":"Crossref","is-referenced-by-count":92,"title":["Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis"],"prefix":"10.1093","volume":"92","author":[{"given":"Z","family":"Kadry","sequence":"first","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Renner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Bachmann","sequence":"additional","affiliation":[{"name":"The Horten Centre, University Hospital Zurich, Zurich, Switzerland"},{"name":"Division of Epidemiology and Biostatistics, Department of Social and Preventive Medicine, University of Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Attigah","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Renner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R W","family":"Ammann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-A","family":"Clavien","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,25]]},"reference":[{"key":"2021070906161836500_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00001432-200310000-00010","article-title":"Echinococcus multilocularis","volume":"16","author":"Craig","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"2021070906161836500_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"2021070906161836500_bib3","first-page":"47","volume-title":"WHO\/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern","author":"Pawlowski","year":"2001"},{"key":"2021070906161836500_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0169-4758(99)01476-3","article-title":"Alveolar echinococcosis in humans: the current situation in central Europe and the need for countermeasures","volume":"15","author":"Eckert","year":"1999","journal-title":"Parasitol Today"},{"key":"2021070906161836500_bib5","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis","volume":"362","author":"McManus","year":"2003","journal-title":"Lancet"},{"key":"2021070906161836500_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0168-8278(89)90037-8","article-title":"Alveolar echinococcosis of the liver","volume":"8","author":"Miguet","year":"1989","journal-title":"J Hepatol"},{"key":"2021070906161836500_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF00930903","article-title":"Improvement of liver resectional therapy by adjuvant chemotherapy in alveolar hydatid disease. 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