{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:59:41Z","timestamp":1773907181159,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T00:00:00Z","timestamp":1120435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Radiofrequency ablation (RFA) is a new treatment for liver tumours. Complications encountered after RFA in the Netherlands were evaluated in the present study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between June 1999 and November 2003 patients undergoing RFA of irresectable liver tumours in eight medical centres were registered prospectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred and forty-three RFA procedures were performed in 122 patients. RFA was combined with partial hepatectomy in 37 instances. Death occurred after two procedures (1\u00b74 per cent), and was mainly due to concomitant partial hepatectomy. A total of 19 major complications occurred after ten procedures, including biliary tract damage (seven patients), liver failure (four), hepatic abscess (three), peritoneal infection (two), intrahepatic haematoma (one), hepatic artery aneurysm (one) and pulmonary embolism (one). Twenty-four minor complications were related to concomitant partial hepatectomy or laparotomy. The overall complication rate was 20\u00b73 per cent and the rate of complications related directly to RFA was 9\u00b78 per cent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The procedure-specific complication rate was almost 10 per cent and it is recommended that RFA should be performed only by an experienced team comprising a hepatobiliary surgeon, gastroenterologist, hepatologist and interventional radiologist. Biliary stricture, hepatic vascular damage and hepatic abscesses were the most common major complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5059","type":"journal-article","created":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T15:18:31Z","timestamp":1120490311000},"page":"1248-1254","source":"Crossref","is-referenced-by-count":62,"title":["Adverse effects of radiofrequency ablation of liver tumours in the Netherlands"],"prefix":"10.1093","volume":"92","author":[{"given":"M C","family":"Jansen","sequence":"first","affiliation":[{"name":"Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F H","family":"van Duijnhoven","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"van Hillegersberg","sequence":"additional","affiliation":[{"name":"University Medical Centre, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rijken","sequence":"additional","affiliation":[{"name":"Amphia Ziekenhuis, Locatie Molengracht, Breda, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"van Coevorden","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"van der Sijp","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Prevoo","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"van Gulik","sequence":"additional","affiliation":[{"name":"Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,4]]},"reference":[{"key":"2021070906174214600_bib1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00000658-199403000-00003","article-title":"Current treatment modalities for hepatocellular carcinoma","volume":"219","author":"Farmer","year":"1994","journal-title":"Ann Surg"},{"key":"2021070906174214600_bib2","first-page":"211","article-title":"Surgical and nonsurgical management of primary and metastatic liver tumors","volume":"64","author":"Zibari","year":"1998","journal-title":"Am Surg"},{"key":"2021070906174214600_bib3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1200\/JCO.1997.15.3.938","article-title":"Liver resection for colorectal metastases","volume":"15","author":"Fong","year":"1997","journal-title":"J Clin Oncol"},{"key":"2021070906174214600_bib4","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/1097-0142(19800515)45:10<2663::AID-CNCR2820451030>3.0.CO;2-G","article-title":"Primary liver cancers in Japan","volume":"45","author":"Anonymous","year":"1980","journal-title":"Cancer"},{"key":"2021070906174214600_bib5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00000658-199503000-00012","article-title":"Hepatic resection for hepatocellular carcinoma. An audit of 343 patients","volume":"221","author":"Lai","year":"1995","journal-title":"Ann Surg"},{"key":"2021070906174214600_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00000658-200009000-00010","article-title":"Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis","volume":"232","author":"Curley","year":"2000","journal-title":"Ann Surg"},{"key":"2021070906174214600_bib7","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/archsurg.137.12.1332","article-title":"A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies","volume":"137","author":"Adam","year":"2002","journal-title":"Arch Surg"},{"key":"2021070906174214600_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/PL00013173","article-title":"World survey on the complications of hepatic and prostate cryotherapy","volume":"23","author":"Seifert","year":"1999","journal-title":"World J Surg"},{"key":"2021070906174214600_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1148\/radiology.197.1.7568806","article-title":"Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection","volume":"197","author":"Livraghi","year":"1995","journal-title":"Radiology"},{"key":"2021070906174214600_bib10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/bjs.4326","article-title":"Interstitial laser thermotherapy for liver tumours","volume":"90","author":"Nikfarjam","year":"2003","journal-title":"Br J Surg"},{"key":"2021070906174214600_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/bjs.4091","article-title":"Interstitial ablative techniques for hepatic tumours","volume":"90","author":"Erce","year":"2003","journal-title":"Br J Surg"},{"key":"2021070906174214600_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1046\/j.1365-2168.1999.01059.x","article-title":"Interstitial laser coagulation for hepatic tumours","volume":"86","author":"Heisterkamp","year":"1999","journal-title":"Br J Surg"},{"key":"2021070906174214600_bib13","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1694::AID-CNCR8>3.0.CO;2-3","article-title":"Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma: comparison with percutaneous ethanol injection therapy","volume":"85","author":"Seki","year":"1999","journal-title":"Cancer"},{"key":"2021070906174214600_bib14","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1002\/lt.20053","article-title":"Multimodal image-guided tailored therapy of early and intermediate hepatocellular carcinoma: long-term survival in the experience of a single radiologic referral center","volume":"10","author":"Livraghi","year":"2004","journal-title":"Liver Transpl"},{"key":"2021070906174214600_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1634\/theoncologist.6-1-24","article-title":"Radiofrequency ablation of unresectable hepatic malignancies: lessons learned","volume":"6","author":"Bilchik","year":"2001","journal-title":"Oncologist"},{"key":"2021070906174214600_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/radiology.205.2.9356616","article-title":"Hepatic metastases: percutaneous radio-frequency ablation with cooled-tip electrodes","volume":"205","author":"Solbiati","year":"1997","journal-title":"Radiology"},{"key":"2021070906174214600_bib17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00129689-200010000-00005","article-title":"Laparoscopic radiofrequency thermal ablation of hepatocarcinoma: preliminary experience","volume":"10","author":"Goletti","year":"2000","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"2021070906174214600_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s004640000067","article-title":"Laparoscopic radiofrequency ablation of primary and metastatic liver tumors. Technical considerations","volume":"14","author":"Siperstein","year":"2000","journal-title":"Surg Endosc"},{"key":"2021070906174214600_bib19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/ejso.2000.1000","article-title":"Usefulness of intraoperative radiofrequency thermoablation of liver tumours associated or not with hepatectomy","volume":"26","author":"Elias","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"2021070906174214600_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1245\/ASO.2004.08.019","article-title":"Local recurrences after intraoperative radiofrequency ablation of liver metastases: a comparative study with anatomic and wedge resections","volume":"11","author":"Elias","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"2021070906174214600_bib21","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1245\/ASO.2003.03.026","article-title":"Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients","volume":"10","author":"Pawlik","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"2021070906174214600_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1148\/radiol.2262012198","article-title":"Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study","volume":"226","author":"Livraghi","year":"2003","journal-title":"Radiology"},{"key":"2021070906174214600_bib23","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1046\/j.1365-2168.2002.02168.x","article-title":"Complications of radiofrequency coagulation of liver tumours","volume":"89","author":"Mulier","year":"2002","journal-title":"Br J Surg"},{"key":"2021070906174214600_bib24","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/01.sla.0000118373.31781.f2","article-title":"Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients","volume":"239","author":"Curley","year":"2004","journal-title":"Ann Surg"},{"key":"2021070906174214600_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-199907000-00001","article-title":"Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients","volume":"230","author":"Curley","year":"1999","journal-title":"Ann Surg"},{"key":"2021070906174214600_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/cncr.11919","article-title":"Radiofrequency ablation: the experts weigh in","volume":"100","author":"Tanabe","year":"2004","journal-title":"Cancer"},{"key":"2021070906174214600_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1148\/radiol.2282021787","article-title":"Image-guided tumor ablation: proposal for standardization of terms and reporting criteria","volume":"228","author":"Goldberg","year":"2003","journal-title":"Radiology"},{"key":"2021070906174214600_bib28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00944177","article-title":"Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria","volume":"10","author":"Green","year":"1992","journal-title":"Invest New Drugs"},{"key":"2021070906174214600_bib29","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00464-002-9273-0","article-title":"Successful treatment of radiofrequency-induced biliary lesions by interventional endoscopic retrograde cholangiography (ERC)","volume":"17","author":"Stippel","year":"2003","journal-title":"Surg Endosc"},{"key":"2021070906174214600_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jamcollsurg.2003.12.026","article-title":"Intraductal cooling of the main bile ducts during radiofrequency ablation prevents biliary stenosis","volume":"198","author":"Elias","year":"2004","journal-title":"J Am Coll Surg"},{"key":"2021070906174214600_bib31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF02725339","article-title":"Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications","volume":"7","author":"Wood","year":"2000","journal-title":"Ann Surg Oncol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.5059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/10\/1248\/36731177\/bjs5059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/10\/1248\/36731177\/bjs5059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T14:44:04Z","timestamp":1625841844000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/92\/10\/1248\/6144361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,4]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2005,7,4]]},"published-print":{"date-parts":[[2005,9,20]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.5059","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,10]]},"published":{"date-parts":[[2005,7,4]]}}}