{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:42:44Z","timestamp":1778989364387,"version":"3.51.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T00:00:00Z","timestamp":1120435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C348\/A3758"],"award-info":[{"award-number":["C348\/A3758"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011529","name":"Scottish Health Department","doi-asserted-by":"publisher","award":["CZF\/1\/13"],"award-info":[{"award-number":["CZF\/1\/13"]}],"id":[{"id":"10.13039\/100011529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011529","name":"Scottish Health Department","doi-asserted-by":"publisher","award":["CZH\/4\/145"],"award-info":[{"award-number":["CZH\/4\/145"]}],"id":[{"id":"10.13039\/100011529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011529","name":"Scottish Health Department","doi-asserted-by":"publisher","award":["K\/OPR\/2\/2\/D333"],"award-info":[{"award-number":["K\/OPR\/2\/2\/D333"]}],"id":[{"id":"10.13039\/100011529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Robust estimates of the prevalence of a family history of colorectal cancer in the general population are essential to inform planning of provision for colonoscopic surveillance and for clinical genetics services. However, there is a paucity of high-quality data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Computerized record linkage was used to assess systematically the family history of 160 cancer-free community subjects and thereby provide prevalence data that are independent of participant recall. The data set comprised 2664 first- and second-degree relatives of study subjects, with 148 068 years at risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of people in the 30\u201370 years age range, 9\u00b74 (95 per cent confidence interval (c.i.) 5\u00b78 to 14\u00b79) per cent had a first-degree relative affected by colorectal cancer, and 28\u00b78 (95 per cent c.i. 22\u00b73 to 36\u00b72) per cent had an affected first- or second-degree relative. Between 0 and 3\u00b71 per cent of study subjects merited colonic surveillance, depending on the stringency of the guidelines used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An appreciable proportion of the general population has a relative affected by colorectal cancer, sufficient to merit screening under certain criteria. In the absence of good-quality evidence supporting colonoscopic surveillance in groups at moderate risk, these data directly inform the planning of services for people with a family history of colorectal cancer. However, the clinical risk and financial implications of screening should be taken into account.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5084","type":"journal-article","created":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T15:32:15Z","timestamp":1120491135000},"page":"1161-1164","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence of family history of colorectal cancer in the general population"],"prefix":"10.1093","volume":"92","author":[{"given":"R J","family":"Mitchell","sequence":"first","affiliation":[{"name":"Colon Cancer Genetics Group, University of Edinburgh, Division of Clinical and Molecular Medicine and Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK"},{"name":"Public Health Sciences, Department of Community Health Sciences, University of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Campbell","sequence":"additional","affiliation":[{"name":"Public Health Sciences, Department of Community Health Sciences, University of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Farrington","sequence":"additional","affiliation":[{"name":"Colon Cancer Genetics Group, University of Edinburgh, Division of Clinical and Molecular Medicine and Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Brewster","sequence":"additional","affiliation":[{"name":"Information and Statistics Division, Common Services Agency for NHS Scotland, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E M","family":"Porteous","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, University of Edinburgh, Western General Hospital, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Colon Cancer Genetics Group, University of Edinburgh, Division of Clinical and Molecular Medicine and Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,4]]},"reference":[{"key":"2021070906203330100_bib1","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/jnci\/86.21.1618","article-title":"Family history of cancer and colon cancer risk: the Utah Population Database","volume":"86","author":"Slattery","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"2021070906203330100_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/jms.8.2.69","article-title":"Prevalence and family history of colorectal cancer: implications for 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