{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:19:13Z","timestamp":1779369553463,"version":"3.53.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Evidence suggests that baseline quality of life (QOL) scores are independently prognostic for survival in patients with cancer, but the role of QOL data in predicting short-term outcome after surgery is uncertain. This study assessed the association between QOL scores and short-term outcomes after surgery for oesophageal and gastric cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients selected for oesophagectomy or total gastrectomy between November 2000 and May 2003 completed the European Organization for Research and Treatment of Cancer's quality of life questionnaire, QLQ-C30. Multivariable regression models, adjusting for known clinical risk factors, were used to investigate relationships between QOL scores, major morbidity, hospital stay and survival status at 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 130 patients, 121 completed the questionnaire (response rate 93\u00b71 per cent). There were 29 major complications (24\u00b70 per cent) and 22 patients (18\u00b72 per cent) died within 6 months of operation. QOL scores were not associated with major morbidity but were significantly related to survival status at 6 months after adjusting for known clinical risk factors. A worse fatigue score of 10 points (scale 0\u2013100) corresponded to an increase in the odds of death within 6 months of surgery of 37\u00b74 (95 per cent confidence interval (c.i.) 12\u00b74 to 67\u00b78) per cent (P = 0\u00b7002). Pretreatment social function scores were moderately associated with hospital stay (P = 0\u00b7021); a reduction in social function by 10 points corresponded to an increase in hospital stay of 0\u00b793 (95 per cent c.i. 0\u00b712 to 1\u00b774) days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>QOL scores supplement standard staging procedures for oesophageal and gastric cancer by providing prognostic information, but they do not contribute to perioperative risk assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5175","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T10:46:30Z","timestamp":1130409990000},"page":"1502-1507","source":"Crossref","is-referenced-by-count":51,"title":["Association between quality of life scores and short-term outcome after surgery for cancer of the oesophagus or gastric cardia"],"prefix":"10.1093","volume":"92","author":[{"given":"J M","family":"Blazeby","sequence":"first","affiliation":[{"name":"Surgery, Clinical Sciences at South Bristol, Bristol, UK"},{"name":"Department of Social Medicine, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nicklin","sequence":"additional","affiliation":[{"name":"Surgery, Clinical Sciences at South Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Barham","sequence":"additional","affiliation":[{"name":"United Bristol Healthcare Trust, Marlborough Street, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alderson","sequence":"additional","affiliation":[{"name":"Surgery, Clinical Sciences at South Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"2021070906195704200_bib1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa022343","article-title":"Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus","volume":"347","author":"Hulscher","year":"2002","journal-title":"N Engl J Med"},{"key":"2021070906195704200_bib2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/bmj.327.7425.1192","article-title":"Mortality and morbidity in gastro-oesphageal cancer surgery: initial results of ASCOT multicentre prospective cohort study","volume":"327","author":"McCulloch","year":"2003","journal-title":"BMJ"},{"key":"2021070906195704200_bib3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(96)90144-0","article-title":"Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer. Preliminary results of the MRC randomised controlled surgical trial. The Surgical Cooperative Group","volume":"347","author":"Cuschieri","year":"1996","journal-title":"Lancet"},{"key":"2021070906195704200_bib4","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1200\/JCO.2004.10.184","article-title":"Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy\u2014Japan Clinical Oncology Group study 9501","volume":"22","author":"Sano","year":"2004","journal-title":"J Clin Oncol"},{"key":"2021070906195704200_bib5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bjs.4596","article-title":"Postoperative mortality following oesophagectomy and problems in reporting its rate","volume":"91","author":"Jamieson","year":"2004","journal-title":"Br J Surg"},{"key":"2021070906195704200_bib6","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1781::AID-CNCR4>3.0.CO;2-G","article-title":"A prospective longitudinal study examining the quality of life of patients with esophageal cancer","volume":"88","author":"Blazeby","year":"2000","journal-title":"Cancer"},{"key":"2021070906195704200_bib7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1046\/j.1365-2168.1998.00663.x","article-title":"Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer","volume":"85","author":"Bartels","year":"1998","journal-title":"Br J Surg"},{"key":"2021070906195704200_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"2021070906195704200_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1200\/JCO.1993.11.3.570","article-title":"The Functional Assessment of Cancer Therapy Scale: development and validation of the general measure","volume":"11","author":"Cella","year":"1993","journal-title":"J Clin Oncol"},{"key":"2021070906195704200_bib10","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/01.sla.0000094304.17672.6e","article-title":"The association of pretreatment health-related quality of life with surgical complications for patients undergoing open surgical resection for colorectal cancer","volume":"238","author":"Anthony","year":"2003","journal-title":"Ann Surg"},{"key":"2021070906195704200_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/gut.49.2.227","article-title":"The prognostic value of quality of life scores during treatment for oesophageal cancer","volume":"49","author":"Blazeby","year":"2001","journal-title":"Gut"},{"key":"2021070906195704200_bib12","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1200\/JCO.2004.08.154","article-title":"Multivariate prognostic factor analysis in locally advanced and metastatic esophago-gastric cancer\u2014pooled analysis from three multicenter, randomized, controlled trials using individual patient data","volume":"22","author":"Chau","year":"2004","journal-title":"J Clin Oncol"},{"key":"2021070906195704200_bib13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.ijrobp.2003.09.100","article-title":"Quality of life as a survival predictor for esophageal squamous cell carcinoma treated with radiotherapy","volume":"58","author":"Fang","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021070906195704200_bib14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1046\/j.1365-2168.1998.00940.x","article-title":"Classification of adenocarcinoma of the oesophagogastric junction","volume":"85","author":"Siewert","year":"1998","journal-title":"Br J Surg"},{"key":"2021070906195704200_bib15","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.ejca.2004.05.023","article-title":"Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-STO 22, to assess quality of life in patients with gastric cancer","volume":"40","author":"Blazeby","year":"2004","journal-title":"Eur J Cancer"},{"key":"2021070906195704200_bib16","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/S0959-8049(03)00270-3","article-title":"Clinical and psychometric validation of an EORTC questionnaire module, the EORTC QLQ-OES18, to assess quality of life in patients with oesophageal cancer","volume":"39","author":"Blazeby","year":"2003","journal-title":"Eur J Cancer"},{"key":"2021070906195704200_bib17","volume-title":"EORTC QLQ-C30 Scoring Manual","author":"Fayers","year":"2001","edition":"3rd"},{"key":"2021070906195704200_bib18","volume-title":"Essential Medical Statistics","author":"Kirkwood","year":"2003","edition":"2nd"},{"key":"2021070906195704200_bib19","volume-title":"UICC. TNM Classification of Malignant Tumours","author":"Sobin","year":"1997","edition":"5th"},{"key":"2021070906195704200_bib20","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1001\/jama.281.14.1298","article-title":"Health-related quality of life as a predictor of mortality following coronary artery bypass graft surgery. Participants of the Department of Veterans Affairs Cooperative Study Group on Processes, Structures, and Outcomes of Care in Cardiac Surgery","volume":"281","author":"Rumsfeld","year":"1999","journal-title":"JAMA"},{"key":"2021070906195704200_bib21","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1200\/JCO.2000.18.22.3768","article-title":"Quality-of-life scores predict outcome in metastatic but not early breast cancer. International Breast Cancer Study Group","volume":"18","author":"Coates","year":"2000","journal-title":"J Clin Oncol"},{"key":"2021070906195704200_bib22","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1200\/JCO.2004.02.060","article-title":"Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: an international multicenter study","volume":"22","author":"Efficace","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.5175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/12\/1502\/36731084\/bjs5175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/92\/12\/1502\/36731084\/bjs5175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T14:46:26Z","timestamp":1625841986000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/92\/12\/1502\/6144412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,27]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2005,10,27]]},"published-print":{"date-parts":[[2005,11,24]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.5175","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,12]]},"published":{"date-parts":[[2005,10,27]]}}}