{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:42:10Z","timestamp":1773081730691,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Local excision after radiotherapy for node-negative low rectal cancer may be an alternative to radical excision. This study evaluated the results of local excision in patients with small (less than 3 cm in diameter) T2 and T3 distal rectal tumours following neoadjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred patients with rectal cancer (54 uT2 and 46 uT3 uN0 tumours) were enrolled. All patients underwent preoperative radiotherapy followed by local excision by means of transanal endoscopic microsurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Definitive histological examination revealed nine pT1, 54 pT2 and 19 pT3 tumours. A complete response (R0) or microscopic residual tumour (R1mic) was found in three and 15 patients respectively. Minor complications occurred in 11 patients and major complications in two. At a median follow-up of 55 (range 7\u2013120) months, the local failure rate was 5 per cent and metastatic disease was found in two patients. The cancer-specific survival rate at 90 months' follow-up was 89 per cent, and the overall survival rate 72 per cent. Salvage abdominoperineal resection was performed in three patients, two of whom were disease free at 15 and 19 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of small uT2 and uT3 uN0 rectal cancers with preoperative high-dose radiotherapy followed by transanal endoscopic microsurgery is an acceptable alternative to conventional radical resection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.5178","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T10:46:36Z","timestamp":1130409996000},"page":"1546-1552","source":"Crossref","is-referenced-by-count":144,"title":["Long-term results in patients with T2\u20133 N0 distal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery"],"prefix":"10.1093","volume":"92","author":[{"given":"E","family":"Lezoche","sequence":"first","affiliation":[{"name":"Department of Surgery \u2018Paride Stefanini\u2019, II Clinica Chirurgica, University \u2018La Sapienza\u2019, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Guerrieri","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Ancona, \u2018Umberto I\u2019 Hospital, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Paganini","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2018Paride Stefanini\u2019, II Clinica Chirurgica, University \u2018La Sapienza\u2019, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Baldarelli","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Ancona, \u2018Umberto I\u2019 Hospital, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Ancona, \u2018Umberto I\u2019 Hospital, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lezoche","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2018Paride Stefanini\u2019, II Clinica Chirurgica, University \u2018La Sapienza\u2019, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"2021070906202938600_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000658-200109000-00009","article-title":"Local excision of T2 and T3 rectal cancers after downstaging chemoradiation","volume":"234","author":"Kim","year":"2001","journal-title":"Ann Surg"},{"key":"2021070906202938600_bib2","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s00268-002-6359-8","article-title":"Long term results of patients with pT2 rectal cancer treated with radiotherapy and transanal endoscopic microsurgical excision","volume":"26","author":"Lezoche","year":"2002","journal-title":"World J Surg"},{"key":"2021070906202938600_bib3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archsurg.134.8.863","article-title":"Local excision of rectal carcinoma","volume":"134","author":"Varma","year":"1999","journal-title":"Arch Surg"},{"key":"2021070906202938600_bib4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/000313480006600903","article-title":"Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology","volume":"66","author":"Blair","year":"2000","journal-title":"Am Surg"},{"key":"2021070906202938600_bib5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s004640080182","article-title":"Local recurrence and survival after laparoscopic mesorectal resection for rectal adenocarcinoma","volume":"16","author":"Poulin","year":"2002","journal-title":"Surg Endosc"},{"key":"2021070906202938600_bib6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/BF02054683","article-title":"Surgical cure for early rectal carcinomas (T1). 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