{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:24:37Z","timestamp":1792621477283,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Parathyroid carcinoma is a rare malignancy affecting 0\u00b75\u20135 per cent of all patients with primary hyperparathyroidism. This article reviews the literature on the pathogenesis, pathology, clinical features, diagnosis and management of parathyroid carcinoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A Medline search was performed and all relevant English language articles published between 1970 and 2005 were retrieved. The search words included \u2018parathyroid carcinoma\u2019, \u2018pathology\u2019, \u2018genetics\u2019, \u2018management\u2019 and \u2018radiotherapy\u2019. Secondary references were obtained from key articles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results and conclusion<\/jats:title>\n                  <jats:p>The exact aetiology of parathyroid carcinoma remains obscure. Recently, the HRPT2 gene has been implicated in its pathogenesis and may prove to be a genetic target in future. Surgical resection is the accepted \u2018gold standard\u2019. There is now a growing consensus on the use of adjuvant radiotherapy as it has been shown to provide a survival benefit.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5182","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T14:18:20Z","timestamp":1129817900000},"page":"1345-1353","source":"Crossref","is-referenced-by-count":70,"title":["Parathyroid carcinoma"],"prefix":"10.1093","volume":"92","author":[{"given":"N","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of General Surgery, Morriston Hospital, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Khetan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Morriston Hospital, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Morriston Hospital, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J N","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Morriston Hospital, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"2021070906214004100_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF02819737","article-title":"Parastruma maligna aberrata","volume":"100","author":"de Quervain","year":"1904","journal-title":"Dtsch Z Chir"},{"key":"2021070906214004100_bib2","first-page":"813","article-title":"Malegne dun adenoma parathyroidiene eosinophile; au cours dune de Recklinghausen","volume":"10","author":"Sainton","year":"1933","journal-title":"Annales Anatomie Pathologique"},{"key":"2021070906214004100_bib3","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/00016480260000184","article-title":"Management of cancer of the parathyroid","volume":"122","author":"Rao","year":"2002","journal-title":"Acta Otolaryngol"},{"key":"2021070906214004100_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.otc.2004.02.014","article-title":"Parathyroid carcinoma","volume":"37","author":"Beus","year":"2004","journal-title":"Otolaryngol Clin North Am"},{"key":"2021070906214004100_bib5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K","article-title":"Two hundred eighty-six cases of parathyroid carcinoma treated in the US between 1985\u20131995: a National Cancer Data Base Report. 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