{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:13:58Z","timestamp":1790864038912,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Health Service Developments in the Organization of Care Projects"},{"name":"Ethicon Endosurgery"},{"name":"Medical Research Council Clinician Scientist Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Laparoscopic resection of colorectal cancer may improve short-term outcome without compromising long-term survival or disease control. Recent evidence suggests that the difference between laparoscopic and open surgery may be less significant when perioperative care is optimized within an enhanced recovery programme. This study compared short-term outcomes of laparoscopic and open resection of colorectal cancer within such a programme.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between January 2002 and March 2004, 62 patients were randomized on a 2 : 1 basis to receive laparoscopic (n = 43) or open (n = 19) surgery. All were entered into an enhanced recovery programme. Length of hospital stay was the primary endpoint. Secondary outcomes of functional recovery, quality of life and cost were assessed for 3 months after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Demographics of the two groups were similar. Length of hospital stay after laparoscopic resection was 32 (95 per cent confidence interval (c.i.) 7 to 51) per cent shorter than for open resection (P = 0\u00b7018). Combined hospital, convalescent and readmission stay was 37 (95 per cent c.i. 10 to 56) per cent shorter (P = 0\u00b7012). The relative risk of complications, quality of life results and cost data were similar in the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite perioperative optimization of open surgery for colorectal cancer, short-term outcomes were better following laparoscopic surgery. There was no deterioration in quality of life or increased cost associated with the laparoscopic approach.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5216","type":"journal-article","created":{"date-parts":[[2005,12,19]],"date-time":"2005-12-19T12:46:49Z","timestamp":1134996409000},"page":"300-308","source":"Crossref","is-referenced-by-count":286,"title":["Randomized clinical trial comparing laparoscopic and open surgery for colorectal cancer within an enhanced recovery programme"],"prefix":"10.1093","volume":"93","author":[{"given":"P M","family":"King","sequence":"first","affiliation":[{"name":"Department of Surgery, Yeovil District Hospital , Yeovil,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Blazeby","sequence":"additional","affiliation":[{"name":"Departments of Social Medicine and Clinical Sciences at South Bristol, University of Bristol , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ewings","sequence":"additional","affiliation":[{"name":"Research and Development Department, Taunton and Somerset Hospital , Taunton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Franks","sequence":"additional","affiliation":[{"name":"Centre for Research and Implementation of Clinical Practice, Thames Valley University , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Longman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yeovil District Hospital , Yeovil,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Kendrick","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Bristol Royal Infirmary , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R 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