{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:37:14Z","timestamp":1773081434359,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recent meta-analysis has questioned the value of bowel preparation in patients undergoing colorectal resection. The aim of this clinical trial was to evaluate whether a single phosphate enema was as effective as oral polyethylene glycol (PEG) solution in preventing anastomotic leakage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomized to receive either a single phosphate enema or 3 litres of oral PEG solution before surgery. Patients were followed for a minimum of 6 weeks to detect anastomotic leakage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 147 patients in each group and the groups were evenly matched for putative risk factors at baseline. Patients in the enema group had more anastomotic leaks requiring reoperation than those in the PEG group (4\u00b71 versus 0 per cent, P = 0\u00b7013; relative risk 2\u00b704 (95 per cent confidence interval (c.i.) 1\u00b782 to 2\u00b730)). The mortality rate was higher in the PEG group (2\u00b77 versus 0\u00b77 per cent, P = 0\u00b7176; odds ratio 1\u00b762 (95 per cent c.i. 0\u00b745 to 36\u00b798)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bowel preparation with a phosphate enema was associated with an increased risk of anastomotic leakage requiring reoperation compared with oral PEG. These results do not support the routine use of a phosphate enema in patients undergoing elective colorectal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.5274","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T13:46:46Z","timestamp":1140443206000},"page":"427-433","source":"Crossref","is-referenced-by-count":57,"title":["Randomized clinical trial of bowel preparation with a single phosphate enema or polyethylene glycol before elective colorectal surgery"],"prefix":"10.1093","volume":"93","author":[{"given":"C","family":"Platell","sequence":"first","affiliation":[{"name":"Colorectal Surgical Unit, Fremantle Hospital, Fremantle, Australia"},{"name":"Department of Surgery, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Barwood","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit, Fremantle Hospital, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Makin","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit, Fremantle Hospital, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,2,20]]},"reference":[{"key":"2021070907264036400_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/BF02235369","article-title":"The role of mechanical bowel preparation in patients undergoing colorectal surgery?","volume":"41","author":"Platell","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"2021070907264036400_bib2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/BF02213131","article-title":"Biochemical effects of oral sodium phosphate","volume":"41","author":"DiPalma","year":"1996","journal-title":"Dig Dis Sci"},{"key":"2021070907264036400_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.5694\/j.1326-5377.2000.tb139295.x","article-title":"Flexible sigmoidoscopy screening for colorectal cancer in average-risk people: update of a community-based project","volume":"173","author":"Collett","year":"2000","journal-title":"Med J Aust"},{"key":"2021070907264036400_bib4","volume-title":"Statistical Methods in Medical Research","author":"Armitage","year":"1994","edition":"3rd"},{"key":"2021070907264036400_bib5","first-page":"461","article-title":"Mechanical bowel preparation before colorectal surgery: results of a prospective randomized trial","volume":"79","author":"Brownson","year":"1991","journal-title":"Br J Surg"},{"key":"2021070907264036400_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/bjs.1800810639","article-title":"Requirement for bowel preparation in colorectal surgery","volume":"81","author":"Burke","year":"1994","journal-title":"Br J Surg"},{"key":"2021070907264036400_bib7","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/bjs.1800811139","article-title":"Prospective randomized trial of mechanical bowel preparation in patients undergoing elective colorectal surgery","volume":"81","author":"Santos","year":"1994","journal-title":"Br J Surg"},{"key":"2021070907264036400_bib8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF02235585","article-title":"Bowel preparation with oral polyethylene glycol electrolyte solution vs. no preparation in elective open colorectal surgery: prospective, randomized study","volume":"43","author":"Miettinen","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"2021070907264036400_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.SLA.0000055222.90581.59","article-title":"Colon and rectal surgery without mechanical bowel preparation. 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