{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:30:19Z","timestamp":1788269419079,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T00:00:00Z","timestamp":1141689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Selective cyclo-oxygenase 2 (COX-2) inhibitors are increasingly prescribed in the perioperative period. Recent recognition of a possible role for COX-2 in wound healing has raised concerns about the safety of their use in surgical practice. Therefore, the influence of celecoxib, a selective COX-2 inhibitor, on early anastomotic healing was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Celecoxib, in doses of 15, 50 or 200 mg per kg per day, was given daily from the day before operation onwards to male Wistar rats that received both ileal and colonic anastomoses. Anastomotic strength was assessed by measuring the breaking strength and bursting pressure on the third day after operation. A second group received a dose of 50 mg per kg per day and a colonic anastomosis only, and healing was assessed on the third and fifth day after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expression of COX-2 protein was upregulated in the anastomotic area. Administration of celecoxib, at all doses tested, resulted in a significantly higher ileal dehiscence rate than in control rats (P = 0\u00b7002). In contrast, colonic anastomoses healed normally within the same animals. The latter was confirmed in rats with colonic anastomoses only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this model, administration of the COX-2 inhibitor celecoxib affected ileal but not colonic anastomotic healing in the early postoperative period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.5288","type":"journal-article","created":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T21:49:49Z","timestamp":1141768189000},"page":"489-497","source":"Crossref","is-referenced-by-count":38,"title":["Selective cyclo-oxygenase 2 inhibition affects ileal but not colonic anastomotic healing in the early postoperative period"],"prefix":"10.1093","volume":"93","author":[{"given":"I H J T","family":"de Hingh","sequence":"first","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M L M","family":"Lomme","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Bleichrodt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,3,7]]},"reference":[{"key":"2021070907273478300_bib1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1096\/fj.03-0645rev","article-title":"Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic","volume":"18","author":"Warner","year":"2004","journal-title":"FASEB J"},{"key":"2021070907273478300_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-200363001-00002","article-title":"The role of COX-2 inhibitors in pain modulation","volume":"63","author":"Camu","year":"2003","journal-title":"Drugs"},{"key":"2021070907273478300_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.0001-5172.2004.00379.x","article-title":"A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain","volume":"48","author":"Romsing","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"2021070907273478300_bib4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/sj.bjp.0703112","article-title":"Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor","volume":"129","author":"Muscara","year":"2000","journal-title":"Br J Pharmacol"},{"key":"2021070907273478300_bib5","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1097\/01.LAB.0000035024.75914.39","article-title":"Wound healing involves induction of cyclooxygenase-2 expression in rat skin","volume":"82","author":"Futagami","year":"2002","journal-title":"Lab Invest"},{"key":"2021070907273478300_bib6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/01.LAB.0000020407.98665.98","article-title":"Both constitutive and inducible prostaglandin H synthase affect dermal wound healing in mice","volume":"82","author":"Laulederkind","year":"2002","journal-title":"Lab Invest"},{"key":"2021070907273478300_bib7","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1046\/j.1523-1747.2002.19501.x","article-title":"The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin","volume":"119","author":"Muller-Decker","year":"2002","journal-title":"J Invest Dermatol"},{"key":"2021070907273478300_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF02554598","article-title":"Prostaglandins in colonic anastomotic healing","volume":"27","author":"Brennan","year":"1984","journal-title":"Dis Colon Rectum"},{"key":"2021070907273478300_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/BF02053201","article-title":"The effect of prostaglandin E1 on colonic anastomotic healing. A comparison study","volume":"33","author":"Terzioglu","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"2021070907273478300_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/BF02049903","article-title":"Effects of diclofenac sodium on intestinal anastomotic healing. Experimental study on the small intestine of rabbits","volume":"34","author":"de Sousa","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"2021070907273478300_bib11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02090163","article-title":"The influence of NSAIDs on experimental intestinal anastomoses","volume":"34","author":"Mastboom","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"2021070907273478300_bib12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/BF02054408","article-title":"Influence of misoprostol, a synthetic prostaglandin E1 analog, on the healing of colonic anastomoses in rats","volume":"37","author":"de Oliveira","year":"1994","journal-title":"Dis Colon Rectum"},{"key":"2021070907273478300_bib13","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/bjs.4722","article-title":"Effects of a selective cyclo-oxygenase 2 inhibitor on colonic anastomotic and skin wound integrity","volume":"91","author":"Cahill","year":"2004","journal-title":"Br J Surg"},{"key":"2021070907273478300_bib14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1067\/msy.2003.27","article-title":"Doxycycline improves wound strength after intestinal anastomosis in the rat","volume":"133","author":"Siemonsma","year":"2003","journal-title":"Surgery"},{"key":"2021070907273478300_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/bjc.1995.355","article-title":"Post-operative levamisole may compromise early healing of experimental intestinal anastomoses","volume":"72","author":"de Waard","year":"1995","journal-title":"Br J Cancer"},{"key":"2021070907273478300_bib16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/bjs.4146","article-title":"Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis","volume":"90","author":"de Hingh","year":"2003","journal-title":"Br J Surg"},{"key":"2021070907273478300_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/path.1594","article-title":"Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome","volume":"203","author":"Volman","year":"2004","journal-title":"J Pathol"},{"key":"2021070907273478300_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-2133.2003.05065.x","article-title":"Selective cyclooxygenase-2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice","volume":"148","author":"Blomme","year":"2003","journal-title":"Br J Dermatol"},{"key":"2021070907273478300_bib19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study","volume":"284","author":"Silverstein","year":"2000","journal-title":"JAMA"},{"key":"2021070907273478300_bib20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1023\/A:1010748316889","article-title":"Gastrointestinal damage induced by celecoxib and rofecoxib in rats","volume":"46","author":"Laudanno","year":"2001","journal-title":"Dig Dis Sci"},{"key":"2021070907273478300_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1902\/jop.2002.73.1.103","article-title":"Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy","volume":"73","author":"Buduneli","year":"2002","journal-title":"J Periodontol"},{"key":"2021070907273478300_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1034\/j.1600-0447.2002.11227.x","article-title":"Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats","volume":"110","author":"Lin","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"2021070907273478300_bib23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1365-2168.2001.01649.x","article-title":"Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model","volume":"88","author":"Syk","year":"2001","journal-title":"Br J Surg"},{"key":"2021070907273478300_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00384-002-0418-3","article-title":"The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat","volume":"17","author":"de Hingh","year":"2002","journal-title":"Int J Colorectal Dis"},{"key":"2021070907273478300_bib25","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans","volume":"104","author":"Bjarnason","year":"1993","journal-title":"Gastroenterology"},{"key":"2021070907273478300_bib26","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2174\/0929867003374219","article-title":"Cyclooxygenase-2 inhibition and side-effects of non-steroidal anti-inflammatory drugs in the gastrointestinal tract","volume":"7","author":"Meyer-Kirchrath","year":"2000","journal-title":"Curr Med Chem"},{"key":"2021070907273478300_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.49.3.443","article-title":"Cyclooxygenase 2\u2014implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives","volume":"49","author":"Halter","year":"2001","journal-title":"Gut"},{"key":"2021070907273478300_bib28","doi-asserted-by":"crossref","first-page":"G967","DOI":"10.1152\/ajpgi.00532.2002","article-title":"PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum","volume":"285","author":"Gookin","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021070907273478300_bib29","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.52.12.1714","article-title":"Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction","volume":"52","author":"Zamuner","year":"2003","journal-title":"Gut"},{"key":"2021070907273478300_bib30","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0090-9556(24)15094-5","article-title":"Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats","volume":"28","author":"Paulson","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"2021070907273478300_bib31","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1517\/14656566.4.12.2193","article-title":"Cyclooxygenase inhibition in cancer prevention and treatment","volume":"4","author":"Anderson","year":"2003","journal-title":"Expert Opin Pharmacother"},{"key":"2021070907273478300_bib32","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.bcp.2004.05.031","article-title":"Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention","volume":"68","author":"Chun","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"2021070907273478300_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/03635465010290062101","article-title":"A cyclooxygenase-2 inhibitor impairs ligament healing in the rat","volume":"29","author":"Elder","year":"2001","journal-title":"Am J Sports Med"},{"key":"2021070907273478300_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/00016470310017802","article-title":"Indomethacin and celecoxib improve tendon healing in rats","volume":"74","author":"Forslund","year":"2003","journal-title":"Acta Orthop Scand"},{"key":"2021070907273478300_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2003.12.017","article-title":"Is there an inhibitory effect of COX-2 inhibitors on bone healing?","volume":"50","author":"Seidenberg","year":"2004","journal-title":"Pharmacol Res"},{"key":"2021070907273478300_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2165\/00003495-200363010-00003","article-title":"The second generation of COX-2 inhibitors: what advantages do the newest offer?","volume":"63","author":"Stichtenoth","year":"2003","journal-title":"Drugs"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.5288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/93\/4\/489\/36685427\/bjs5288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bjs\/article-pdf\/93\/4\/489\/36685427\/bjs5288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T23:11:34Z","timestamp":1736291494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/93\/4\/489\/6151432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,7]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,3,7]]},"published-print":{"date-parts":[[2006,3,22]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.5288","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4]]},"published":{"date-parts":[[2006,3,7]]}}}