{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:39:15Z","timestamp":1790055555656,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study analysed the value of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary lymph node involvement in women with breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In the first 150 women in this prospective study, axillary lymph node dissection (ALND) was performed regardless of the PET results. In a second group (125 women) FDG-PET was complemented with sentinel lymph node biopsy (SLNB) only in those who did not have pathological axillary uptake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The sensitivity and specificity of FDG-PET in detecting axillary involvement was 84\u00b75 and 98\u00b75 per cent respectively in the whole series of 275 patients, with two false-positive and 22 false-negative results. False-negative results were associated with some intrinsic tumour characteristics. In 21 women, PET revealed pathological uptake, suggesting involvement of the internal mammary lymph node chain. Whole-body PET identified a second synchronous tumour in five asymptomatic patients and haematogenous metastases in two patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The high positive predictive value of PET (98\u00b74 per cent) suggests that FDG uptake in the axilla could be an indication for full ALND without previous SLNB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5338","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T14:42:09Z","timestamp":1145371329000},"page":"707-712","source":"Crossref","is-referenced-by-count":64,"title":["Fluorodeoxyglucose positron emission tomography with sentinel lymph node biopsy for evaluation of axillary involvement in breast cancer"],"prefix":"10.1093","volume":"93","author":[{"given":"A","family":"Gil-Rendo","sequence":"first","affiliation":[{"name":"Department of General Surgery, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Beorlegui","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Clinica Universitaria of Navarra, C\/P\u00edo XII 36, 31008 Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cervera","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Clinica Universitaria of Navarra, C\/P\u00edo XII 36, 31008 Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,18]]},"reference":[{"key":"2021070910553104300_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H","article-title":"Relation of tumor size, lymph node status, and survival in 24 740 breast cancer 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