{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:53:40Z","timestamp":1774382020221,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T00:00:00Z","timestamp":1150416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study examined quality of life (QoL) after classical partial pancreaticoduodenectomy (PPD) and pylorus-preserving pancreaticoduodenectomy (PPPD) in patients with adenocarcinoma of the pancreatic head, and also evaluated the influence of extended lymphadenectomy (ELA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between January 1993 and March 2004, QoL was analysed in a prospective single-centre study that included 91 patients. Thirty-four patients underwent PPD and 57 had a PPPD. Seventy patients had an ELA and 21 underwent regional lymphadenectomy (RLA). QoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire and a pancreatic cancer-specific module. Data were collected before operation and for 24 months after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall 5-year survival rate was 18 per cent for all patients and 21 per cent in those who had an R0 resection. QoL was impaired for 3\u20136 months after surgery and then recovered to preoperative levels. There was no significant difference in long-term survival after PPD versus PPPD and ELA versus RLA. Patients who had ELA reported clinically significant higher levels of diarrhoea and pain. PPPD showed a disadvantage in terms of pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The surgical techniques of resection and reconstruction did not affect QoL, but extended lymphadenectomy was associated with an impairment in QoL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5371","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T12:02:59Z","timestamp":1150459379000},"page":"1099-1107","source":"Crossref","is-referenced-by-count":89,"title":["Quality of life after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head"],"prefix":"10.1093","volume":"93","author":[{"given":"B","family":"Schniewind","sequence":"first","affiliation":[{"name":"Clinic for General and Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Bestmann","sequence":"additional","affiliation":[{"name":"Clinic for General and Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Henne-Bruns","sequence":"additional","affiliation":[{"name":"Clinic for Visceral and Transplantation Surgery, University Clinic of Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Faendrich","sequence":"additional","affiliation":[{"name":"Clinic for General and Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Kremer","sequence":"additional","affiliation":[{"name":"Clinic for General and Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kuechler","sequence":"additional","affiliation":[{"name":"Clinic for General and Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,6,16]]},"reference":[{"key":"2021070910575226500_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2168.1999.01074.x","article-title":"Prospective randomized comparison between pylorus-preserving and standard pancreaticoduodenectomy","volume":"86","author":"Lin","year":"1999","journal-title":"Br J Surg"},{"key":"2021070910575226500_bib2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000658-199905000-00003","article-title":"Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome","volume":"229","author":"Yeo","year":"1999","journal-title":"Ann Surg"},{"key":"2021070910575226500_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1067\/mcn.2002.129579","article-title":"Pancreatic cancer","volume":"26","author":"Yeo","year":"2002","journal-title":"Curr Probl Cancer"},{"key":"2021070910575226500_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0039-6109(05)70143-2","article-title":"Pancreatic cancer: the bigger picture","volume":"81","author":"Cooperman","year":"2001","journal-title":"Surg Clin North Am"},{"key":"2021070910575226500_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0039-6109(16)46738-1","article-title":"Long-term survival following pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas","volume":"75","author":"Cameron","year":"1995","journal-title":"Surg Clin North Am"},{"key":"2021070910575226500_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1091-255X(00)80105-5","article-title":"Resected adenocarcinoma of the pancreas\u2014616 patients: results, outcomes, and prognostic indicators","volume":"4","author":"Sohn","year":"2000","journal-title":"J Gastrointest Surg"},{"key":"2021070910575226500_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00000658-199501000-00007","article-title":"Long-term survival after resection for ductal adenocarcinoma of the pancreas. 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