{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:31Z","timestamp":1786977211779,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T00:00:00Z","timestamp":1150416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A blinded randomized clinical trial was undertaken to evaluate the effect of applying ointment to a wound before occlusive dressing, in comparison with no ointment or sterile paraffin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Some 778 patients with 1801 surgical wounds following excision of skin lesions were enrolled in the trial. No ointment was placed on 510 sutured wounds of 247 patients, paraffin ointment was put on 729 wounds (269 patients) and mupirocin ointment on 562 wounds (262 patients). Wound infection, scar, haemorrhage, dehiscence and other complications were assessed at suture removal. At 6\u20139 months after surgery, patients were surveyed to assess the wounds, with a response rate of 74\u00b70 per cent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences in outcome for all endpoints evaluated. The infection rate was 1\u00b74 per cent with no ointment, 1\u00b76 per cent for paraffin and 2\u00b73 per cent for mupirocin (P = 0\u00b7490). Total complication rates were 3\u00b75, 4\u00b77 and 4\u00b78 per cent for no ointment, paraffin and mupirocin respectively (P = 0\u00b7590). Some 10\u00b79, 10\u00b73 and 8\u00b72 per cent of patients respectively had a neutral or negative perception of their wounds at 6\u20139 months after surgery (P = 0\u00b7650). There was no difference in postoperative pain, degree of inconvenience or overall level of satisfaction with treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Putting ointment on a surgical wound before occlusive dressing does not benefit the patient. In view of the risk of antibiotic resistance, mupirocin ointment is not indicated for clean surgical wounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.5400","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T07:35:42Z","timestamp":1150443342000},"page":"937-943","source":"Crossref","is-referenced-by-count":76,"title":["Randomized clinical trial of the effect of applying ointment to surgical wounds before occlusive dressing"],"prefix":"10.1093","volume":"93","author":[{"given":"A J","family":"Dixon","sequence":"first","affiliation":[{"name":"Skin Alert Skin Cancer Clinics, Alfred Hospital, Melbourne, Victoria, Australia"},{"name":"Skincanceronly, Geelong, Alfred Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Dixon","sequence":"additional","affiliation":[{"name":"Skincanceronly, Geelong, Alfred Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Dixon","sequence":"additional","affiliation":[{"name":"Monash University Department of Surgery, Alfred Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,16]]},"reference":[{"key":"2021070910533685700_bib1","volume-title":"Surgical Dermatology","author":"Eedy","year":"1996"},{"key":"2021070910533685700_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0733-8635(05)70485-X","article-title":"Dressing the part","volume":"16","author":"Cho","year":"1998","journal-title":"Dermatol Clin"},{"key":"2021070910533685700_bib3","first-page":"620","article-title":"Topical antibacterial agents for wound care: a primer","volume":"29","author":"Spann","year":"2003","journal-title":"Dermatol Surg"},{"key":"2021070910533685700_bib4","first-page":"91","article-title":"Antibiotic prophylaxis in dermatologic surgery: updated guidelines. 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