{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:37:49Z","timestamp":1787636269208,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ileal pouch\u2013anal anastomosis (IPAA) is performed routinely for chronic ulcerative colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from a prospective database and annual standardized questionnaires, functional outcome, complications and quality of life (QoL) after IPAA were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Some 1885 IPAA operations were performed for chronic ulcerative colitis over a 20-year period (mean follow-up 11 years). The mean age at the time of IPAA was 34\u00b71 years, increasing from 31\u00b72 years (1981\u20131985) to 36\u00b73 years (1996\u20132000). The overall rate of pouch success at 5, 10, 15 and 20 years was 96\u00b73, 93\u00b73, 92\u00b74 and 92\u00b71 per cent respectively. Mean daytime stool frequency increased from 5\u00b77 at 1 year to 6\u00b74 at 20 years (P &amp;lt; 0\u00b7001), and also increased at night (from 1\u00b75 to 2\u00b70; P &amp;lt; 0\u00b7001). The incidence of frequent daytime faecal incontinence increased from 5 to 11 per cent during the day (P &amp;lt; 0\u00b7001) and from 12 to 21 per cent at night (P &amp;lt; 0\u00b7001). QoL remained unchanged and 92 per cent remained in the same employment. Seventy-six patients were eventually diagnosed with indeterminate colitis and 47 with Crohn's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IPAA is a reliable surgical procedure for patients requiring proctocolectomy for chronic ulcerative colitis and indeterminate colitis. The clinical and functional outcomes are excellent and stable for 20 years after operation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.5464","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T04:02:21Z","timestamp":1168920141000},"page":"333-340","source":"Crossref","is-referenced-by-count":347,"title":["Results at up to 20 years after ileal pouch\u2013anal anastomosis for chronic ulcerative colitis"],"prefix":"10.1093","volume":"94","author":[{"given":"D","family":"Hahnloser","sequence":"first","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B 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