{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:53:59Z","timestamp":1787496839520,"version":"build-2736575974"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T00:00:00Z","timestamp":1170028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This randomized clinical trial compared long-term outcome after antireflux surgery with acid inhibition therapy in the treatment of chronic gastro-oesophageal reflux disease (GORD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with chronic GORD and oesophagitis verified at endoscopy were allocated to treatment with omeprazole (154 patients) or antireflux surgery (144). After 7 years of follow-up, 119 patients in the omeprazole arm and 99 who had antireflux surgery were available for evaluation. The primary outcome variable was the cumulative proportion of patients in whom treatment failed. Secondary objectives were evaluation of the treatment failure rate after dose adjustment of omeprazole, safety, and the frequency and severity of post-fundoplication complaints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proportion of patients in whom treatment did not fail during the 7 years was significantly higher in the surgical than in the medical group (66\u00b77 versus 46\u00b77 per cent respectively; P = 0\u00b7002). A smaller difference remained after dose adjustment in the omeprazole group (P = 0\u00b7045). More patients in the surgical group complained of symptoms such as dysphagia, inability to belch or vomit, and rectal flatulence. These complaints were fairly stable throughout the study interval. The mean daily dose of omeprazole was 22\u00b78, 24\u00b71, 24\u00b73 and 24\u00b73 mg at 1, 3, 5 and 7 years respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic GORD can be treated effectively by either antireflux surgery or omeprazole therapy. After 7 years, surgery was more effective in controlling overall disease symptoms, but specific post-fundoplication complaints remained a problem. There appeared to be no dose escalation of omeprazole with time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.5492","type":"journal-article","created":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T07:43:01Z","timestamp":1170056581000},"page":"198-203","source":"Crossref","is-referenced-by-count":134,"title":["Seven-year follow-up of a randomized clinical trial comparing proton-pump inhibition with surgical therapy for reflux oesophagitis"],"prefix":"10.1093","volume":"94","author":[{"given":"L","family":"Lundell","sequence":"first","affiliation":[{"name":"Department of Surgery, Karolinska University Hospital, Huddinge and Ersta Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Miettinen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine, University Hospital Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H E","family":"Myrvold","sequence":"additional","affiliation":[{"name":"Department of Surgery, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Hatlebakk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Wallin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Malm","sequence":"additional","affiliation":[{"name":"Astra Zeneca Research and Development, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Astra Zeneca Research and Development, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Walan","sequence":"additional","affiliation":[{"name":"Astra Zeneca Research and Development, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"2021070911042757600_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000200911","article-title":"Epidemiology and natural history of gastro-oesophageal reflux disease","volume":"51","author":"Spechler","year":"1992","journal-title":"Digestion"},{"key":"2021070911042757600_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00365528909091032","article-title":"Epidemiology of reflux disease and reflux esophagitis","volume":"156","author":"Wienbeck","year":"1989","journal-title":"Scand J Gastroenterol Suppl"},{"key":"2021070911042757600_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2036.1997.tb00796.x","article-title":"Measurement of the impact of heartburn and dyspepsia on quality of life","volume":"11","author":"Glise","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"2021070911042757600_bib4","first-page":"322","article-title":"Medical treatment of reflux esophagitis","volume":"39","author":"Olbe","year":"1992","journal-title":"Hepatogastroenterology"},{"key":"2021070911042757600_bib5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199510263331703","article-title":"A comparison of maintenance therapies for reflux esophagitis","volume":"333","author":"Vigneri","year":"1995","journal-title":"N Engl J Med"},{"key":"2021070911042757600_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1365-2036.1997.00167.x","article-title":"Prognostic factors influencing relapse of oesophagitis during maintenance therapy with antisecretory drugs: a meta-analysis of long-term omeprazole trials","volume":"11","author":"Carlsson","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"2021070911042757600_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01565907","article-title":"Fundoplication for the treatment of gastroesophageal reflux in hiatal hernia","volume":"1","author":"Rossetti","year":"1977","journal-title":"World J Surg"},{"key":"2021070911042757600_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/bjs.1800800118","article-title":"Outcome 5 years after 360\u00b0 fundoplication for gastro-oesophageal reflux disease","volume":"80","author":"Johansson","year":"1993","journal-title":"Br J Surg"},{"key":"2021070911042757600_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-198607000-00002","article-title":"Nissen fundoplication for gastro-esophageal reflux disease. 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