{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:04:06Z","timestamp":1774289046770,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this randomized clinical trial was to determine whether a single intravenous dose of 2 g flucloxacillin could prevent wound infection after primary non-reconstructive breast surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 618 patients undergoing local excision (n = 490), mastectomy (n = 107) or microdochectomy (n = 21). Patients were randomized to receive either a single dose of flucloxacillin immediately after the induction of anaesthesia or no intervention. Wound morbidity was monitored by an independent research nurse for 42 days after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of wound infection was similar in the two groups: 10 of 311 (3\u00b72 per cent) in the flucloxacillin group and 14 of 307 (4\u00b76 per cent) in the control group (\u03c72 = 0\u00b775, P = 0\u00b7387; relative risk 0\u00b771, 95 per cent confidence interval 0\u00b732 to 1\u00b753). The groups also had similar wound scores and rates of moderate or severe cellulitis. Wound infection presented a median of 16 days after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The administration of a single dose of flucloxacillin failed to reduce the rate of wound infection after non-reconstructive breast surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.5505","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T11:27:28Z","timestamp":1158838048000},"page":"1342-1346","source":"Crossref","is-referenced-by-count":37,"title":["Randomized clinical trial of single-dose antibiotic prophylaxis for non-reconstructive breast surgery"],"prefix":"10.1093","volume":"93","author":[{"given":"J C","family":"Hall","sequence":"first","affiliation":[{"name":"School of Surgery and Pathology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Willsher","sequence":"additional","affiliation":[{"name":"School of Surgery and Pathology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Surgery and Pathology, Royal Perth Hospital, University of Western Australia, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,9,21]]},"reference":[{"key":"2021070910565161100_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0195-6701(00)90834-X","article-title":"Antibiotic prophylaxis for patients undergoing breast surgery","volume":"46","author":"Hall","year":"2000","journal-title":"J Hosp Infect"},{"key":"2021070910565161100_bib2","first-page":"866","article-title":"Levofloxacin for prophylaxis in breast cancer surgery compared with ofloxacin","volume":"55","author":"Morimoto","year":"2002","journal-title":"Jpn J Antibiot"},{"key":"2021070910565161100_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000007186","article-title":"Long-acting versus short-acting cephalosporins for preoperative prophylaxis in breast surgery: a randomized double-blind trial involving 1766 patients","volume":"45","author":"Thomas","year":"1999","journal-title":"Chemotherapy"},{"key":"2021070910565161100_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1179\/joc.2001.13.Supplement-2.96","article-title":"Antibiotic prophylaxis in clean surgery: clean non-implant wounds","volume":"13","author":"Leaper","year":"2001","journal-title":"J Chemother"},{"key":"2021070910565161100_bib5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0039-6060(05)80044-3","article-title":"Should antibiotic prophylaxis be used routinely in clean surgical procedures: a tentative yes","volume":"118","author":"Lewis","year":"1995","journal-title":"Surgery"},{"key":"2021070910565161100_bib6","first-page":"12","article-title":"A prospective, randomized double-blind study of the use of antibiotics at the time of mastectomy","volume":"170","author":"Wagman","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"2021070910565161100_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1056\/NEJM199001183220303","article-title":"Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery","volume":"322","author":"Platt","year":"1990","journal-title":"N Engl J Med"},{"key":"2021070910565161100_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0002-9610(98)00154-8","article-title":"Prospective, randomized, double-blind study of prophylactic antibiotics in axillary lymph node dissection","volume":"176","author":"Bold","year":"1998","journal-title":"Am J Surg"},{"key":"2021070910565161100_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1053\/ejso.1999.0899","article-title":"Antibiotic prophylaxis for post-operative wound infection in clean elective breast surgery","volume":"26","author":"Gupta","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"2021070910565161100_bib10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1075-122X.2004.21401.x","article-title":"The measurement of wound infection after breast surgery","volume":"10","author":"Hall","year":"2004","journal-title":"Breast J"},{"key":"2021070910565161100_bib11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cpt1972134609","article-title":"Clinical biostatistics. 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