{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:27:42Z","timestamp":1649158062309},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Genetic mutations and upregulation of growth factors are implicated in the pathogenesis of hyperparathyroidism. The aim of this study was to evaluate the role of Wilms' tumour suppressor gene (WT-1) and the insulin-like growth factor (IGF) axis in hyperparathyroidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The expression of WT-1 and IGF components was examined by immunohistochemistry, reverse transcriptase\u2013polymerase chain reaction and western immunoblotting in a panel of parathyroid specimens from both primary and secondary hyperparathyroidism. A human parathyroid cell culture model was established to examine the parathyroid response to IGF stimulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was a significantly lower level of WT-1 expression in parathyroid tumours than in normal parathyroid glands. Most tumours expressed IGF-I and IGF-II receptors and responded to IGF stimulation. Only IGF-I was present in normal parathyroid glands, whereas IGF-II was expressed exclusively in parathyroid tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Abnormal expression of WT-1 and the IGF axis may play a role in the pathogenesis of hyperparathyroidism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5566","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T16:22:29Z","timestamp":1185812549000},"page":"1232-1241","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the insulin-like growth factor axis and Wilms' tumour suppressor gene in hyperparathyroidism"],"prefix":"10.1093","volume":"94","author":[{"given":"C K M","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery, Frenchay Hospital, Bristol, 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H","family":"Stewart","sequence":"additional","affiliation":[{"name":"Division of Surgery Anaesthetic and Radiological Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Farndon","sequence":"additional","affiliation":[{"name":"Division of Surgery Anaesthetic and Radiological Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"2021070907383273300_bib1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199910213411701","article-title":"A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery","volume":"341","author":"Silverberg","year":"1999","journal-title":"N Engl J 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