{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:53:56Z","timestamp":1790438036371,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:00:00Z","timestamp":1172016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During endotoxaemia, neutrophils activated by inflammatory cytokines release reactive oxygen species and neutrophil elastase, resulting in hepatic necrosis and dysfunction. This study investigated the possible mechanism underlying the protective effect of sivelestat, a neutrophil elastase inhibitor, on endotoxin-induced liver injury following partial hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lipopolysaccharide (LPS) was administered intravenously to male Sprague\u2013Dawley rats 48 h after 70 per cent hepatectomy. Sivelestat or normal saline was given intravenously before LPS administration,<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with sivelestat significantly improved the survival rate. Sivelestat prevented increases in the concentration of serum enzymes and total bilirubin related to liver injury. Levels of inflammatory cytokines in serum and liver tissue were significantly lower in the sivelestat-treated group than in the control group. The degree of neutrophil infiltration, necrosis and apoptosis in the remnant liver was significantly decreased in sivelestat-treated rats. Sivelestat pretreatment inhibited the activation of nuclear factor (NF) \u03baB, caspase 3 and 8 activities, and cytochrome c release.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sivelestat prevents LPS-induced liver injury by inhibition of NF-\u03baB activation and apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.5625","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T18:31:14Z","timestamp":1172082674000},"page":"609-619","source":"Crossref","is-referenced-by-count":21,"title":["Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy"],"prefix":"10.1093","volume":"94","author":[{"given":"A-H","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Surgery, Kansai Medical University, 10\u201315 Fumizono, Moriguchi, Osaka 570-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kansai Medical University, 10\u201315 Fumizono, Moriguchi, Osaka 570-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"key":"2021070911054385300_bib1","first-page":"1499","article-title":"Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy","volume":"22","author":"Boermeester","year":"1995","journal-title":"Hepatology"},{"key":"2021070911054385300_bib2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0016-5085(90)90967-6","article-title":"Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in 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