{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:36:16Z","timestamp":1772793376756,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:00:00Z","timestamp":1172102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical resection remains the treatment of choice for primary and secondary liver cancer. Complications are mainly related to blood loss. Radiofrequency-assisted liver resection (RF-R) has been proposed for parenchymal division as an alternative to clamp crushing in order to reduce blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients (median age 62 (range 30\u201382) years) undergoing hepatectomy were randomized to RF-R (24 patients) or the clamp-crushing method (26). In the RF-R group the resection plane was precoagulated by multiple insertion of a planar triple-cooled radiofrequency ablation needle, and then the parenchyma was sectioned using a scalpel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two groups were well matched in terms of age, sex, liver disease and type of resection. There were no deaths. Eight in the RF-R group developed complications (abscess in six, biliary fistula in three and biliary stenosis in one) compared with none of those who had resection by the crush method (P &amp;lt; 0\u00b7001). Two patients with cirrhosis in each group developed decompensation. Blood transfusion was required in eight of 24 patients in the RF-R group and 13 of 26 in the clamp-crushing group (P = 0\u00b7079).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RF-R allows parenchymal resection in a clean surgical field but is associated with a higher rate of postoperative complications than the clamp-crushing technique.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bjs.5674","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T14:58:08Z","timestamp":1172156288000},"page":"287-291","source":"Crossref","is-referenced-by-count":69,"title":["Randomized clinical trial of radiofrequency-assisted<i>versus<\/i>clamp-crushing liver resection"],"prefix":"10.1093","volume":"94","author":[{"given":"L","family":"Lupo","sequence":"first","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gallerani","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Panzera","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Tandoi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Di Palma","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Memeo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, piazza Giulio Cesare 12, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,2,22]]},"reference":[{"key":"2021070911032980600_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00000658-200210000-00001","article-title":"Improvement in perioperative outcome after hepatic resection: analysis of 1803 consecutive cases over the past 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