{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:15:42Z","timestamp":1774991742800,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:00:00Z","timestamp":1173052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic pancreatitis (CP) is characterized by intractable abdominal pain, and pancreatic exocrine and endocrine dysfunction. This study investigated whether early surgical drainage of pancreatic duct obstruction leads to improved recovery of pancreatic function compared with late surgical drainage in an experimental model of chronic obstructive pancreatitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-one piglets underwent pancreatic duct ligation and subsequent longitudinal pancreaticojejunostomy after 3 weeks (early drainage) or 6 weeks (late drainage), and drainage continued for 6 weeks. In controls with CP pancreatic duct ligation was continued for 12 weeks without a drainage procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Histological pancreatitis scores decreased with early drainage (P = 0\u00b7005), but not with late drainage. Pancreatic secretion of amylase and lipase was restored after early but not late drainage (P = 0\u00b7003 and P = 0\u00b7048 respectively). Excretion levels of lipase were restored to near-baseline preligation levels after early drainage. Pancreatic endocrine function (glucose tolerance test) showed no insufficiency in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this model of early versus late surgical drainage of obstructive pancreatitis, histology grades and pancreatic exocrine function showed improvement in the early drainage group but no recovery in the late drainage group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5722","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T12:24:27Z","timestamp":1173097467000},"page":"849-854","source":"Crossref","is-referenced-by-count":33,"title":["Early <i>versus<\/i> late surgical drainage for obstructive pancreatitis in an experimental model"],"prefix":"10.1093","volume":"94","author":[{"given":"B","family":"Lamme","sequence":"first","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Boermeester","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I H","family":"Straatsburg","sequence":"additional","affiliation":[{"name":"Surgical Laboratory, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"van Buijtenen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Boerma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J A","family":"Offerhaus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Gouma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"van Gulik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands"},{"name":"Surgical Laboratory, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,3,5]]},"reference":[{"key":"2021070907295878900_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01670539","article-title":"Surgical management of chronic pancreatitis on the continent of Europe","volume":"14","author":"Cuilleret","year":"1990","journal-title":"World J Surg"},{"key":"2021070907295878900_bib2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0039-6060(99)70137-6","article-title":"Surgical decompression of ductal obstruction in patients with chronic pancreatitis","volume":"126","author":"Lucas","year":"1999","journal-title":"Surgery"},{"key":"2021070907295878900_bib3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/00000658-196012000-00015","article-title":"Modified Puestow procedure for retrograde drainage of the pancreatic duct","volume":"152","author":"Partington","year":"1960","journal-title":"Ann Surg"},{"key":"2021070907295878900_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00000658-198809000-00009","article-title":"Operative drainage of the pancreatic duct delays functional impairment in patients with chronic pancreatitis. 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