{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:30:08Z","timestamp":1777692608014,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010805","name":"Health Research Council of South-East Sweden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recent studies have suggested that MBP does not lower the risk of postoperative septic complications after elective colorectal surgery. This randomized clinical trial assessed whether preoperative MBP is beneficial in elective colonic surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1505 patients, aged 18\u201385 years with American Society of Anesthesiologists grades I\u2013III, were randomized to MBP or no MBP before open elective surgery for cancer, adenoma or diverticular disease of the colon. Primary endpoints were cardiovascular, general infectious and surgical-site complications within 30 days, and secondary endpoints were death and reoperations within 30 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1343 patients were evaluated, 686 randomized to MBP and 657 to no MBP. There were no significant differences in overall complications between the two groups: cardiovascular complications occurred in 5\u00b71 and 4\u00b76 per cent respectively, general infectious complications in 7\u00b79 and 6\u00b78 per cent, and surgical-site complications in 15\u00b71 and 16\u00b71 per cent. At least one complication was recorded in 24\u00b75 per cent of patients who had MBP and 23\u00b77 per cent who did not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MBP does not lower the complication rate and can be omitted before elective colonic resection. Registration number: ISRCTN28535118 (http:\/\/www.controlled-trials.com).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5816","type":"journal-article","created":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T20:46:23Z","timestamp":1179866783000},"page":"689-695","source":"Crossref","is-referenced-by-count":205,"title":["Multicentre randomized clinical trial of mechanical bowel preparation in elective colonic resection"],"prefix":"10.1093","volume":"94","author":[{"given":"B","family":"Jung","sequence":"first","affiliation":[{"name":"University of Ume\u00e5 and Department of Surgery, Visby Hospital, Visby, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"P\u00e5hlman","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Department of Surgery, Academic Hospital, Uppsala, Visby, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P-O","family":"Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Department of Gastrointestinal Surgery, Karolinska University Hospital Huddinge, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"2021070911045160000_bib1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/BF02234614","article-title":"Bowel preparation for colorectal surgery","volume":"44","author":"Zmora","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"2021070911045160000_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/bjs.1800650809","article-title":"Influence of bowel preparation and antimicrobials on colonic microflora","volume":"65","author":"Arabi","year":"1978","journal-title":"Br J Surg"},{"key":"2021070911045160000_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/bjs.1800740711","article-title":"Mechanical bowel preparation for colonic resection and anastomosis","volume":"74","author":"Irving","year":"1987","journal-title":"Br J Surg"},{"key":"2021070911045160000_bib4","first-page":"347","article-title":"Asepsis in large-bowel surgery","volume":"51","author":"Hughes","year":"1972","journal-title":"Ann R Coll Surg Engl"},{"key":"2021070911045160000_bib5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF02235585","article-title":"Bowel preparation with oral polyethylene glycol electrolyte solution Versus. no preparation in elective open colorectal surgery: prospective, randomized study","volume":"43","author":"Miettinen","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"2021070911045160000_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.SLA.0000055222.90581.59","article-title":"Colon and rectal surgery without mechanical bowel preparation: a randomized prospective trial","volume":"237","author":"Zmora","year":"2003","journal-title":"Ann Surg"},{"key":"2021070911045160000_bib7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/bjs.1800810639","article-title":"Requirement for bowel preparation in colorectal surgery","volume":"81","author":"Burke","year":"1994","journal-title":"Br J Surg"},{"key":"2021070911045160000_bib8","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/bjs.1800811139","article-title":"Prospective randomized trial of mechanical bowel preparation in patients undergoing elective colorectal surgery","volume":"81","author":"Santos","year":"1994","journal-title":"Br J Surg"},{"key":"2021070911045160000_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/bjs.4900","article-title":"Randomized clinical trial of mechanical bowel preparation versus no preparation before elective left-sided colorectal surgery","volume":"92","author":"Bucher","year":"2005","journal-title":"Br J Surg"},{"key":"2021070911045160000_bib10","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s10350-005-0068-y","article-title":"Mechanical bowel preparation or not? 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