{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:23:29Z","timestamp":1773048209923,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study examined the effects of a single dose of intra-anal l-erythro methoxamine on mean anal resting pressure (MARP) and cardiovascular variables in patients with faecal incontinence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients had anorectal physiology tests and ultrasonography before participating. Six patients received 0\u00b73 and 1 per cent gels on separate days, two patients received 0\u00b73 per cent gel, and two patients received 1 per cent gel. MARP, blood pressure, pulse rate and plasma drug concentrations were measured for 6 h after application.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Intra-anal 0\u00b73 per cent gel caused a rapid, significant rise in MARP lasting 2 h (P = 0\u00b7036). In four of these patients, the response was sufficient to increase MARP to within the normal range at 2 h. Application of 1 per cent gel caused a significant rise in MARP for 4 h after application (P = 0\u00b7028). There was a significant decrease in pulse at 2 and 1 h respectively after application of 0\u00b73 and 1 per cent gels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Intra-anal application of l-erythro methoxamine can be used to increase MARP in patients with faecal incontinence. Application of 1 per cent l-erythro methoxamine gel produced a rapid, sustained rise in MARP, which raises the possibility of therapeutic application.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5821","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T11:47:07Z","timestamp":1180698427000},"page":"1155-1161","source":"Crossref","is-referenced-by-count":9,"title":["Intra-anal application of <scp>l<\/scp>-erythro methoxamine gel increases anal resting pressure in patients with incontinence"],"prefix":"10.1093","volume":"94","author":[{"given":"P J","family":"Nisar","sequence":"first","affiliation":[{"name":"Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-J","family":"Gruss","sequence":"additional","affiliation":[{"name":"Constipation and Stool Incontinence Research Group, Department of Geriatrics, University of Witten\/Herdecke, Witten, Germany"},{"name":"Clinical Development, Norgine International Ltd, Harefield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bush","sequence":"additional","affiliation":[{"name":"Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Acheson","sequence":"additional","affiliation":[{"name":"Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Scholefield","sequence":"additional","affiliation":[{"name":"Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"2021070907304883900_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF01646870","article-title":"The composition of anal basal pressure. 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