{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:42:22Z","timestamp":1787161342329,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidural analgesia (EA) with local anaesthetic is considered to play a key role after colorectal surgery. However, its effect on postoperative recovery is still a matter of debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of randomized controlled trials comparing postoperative EA and parenteral opioid analgesia after colorectal surgery was performed. The effect on postoperative recovery was evaluated in terms of length of hospital stay, pain intensity, duration of postoperative ileus, incidence of postoperative complications and side-effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen trials published between 1987 and 2005 were included. EA significantly reduced pain scores and duration of ileus (weighted mean difference \u2212 1\u00b755 (95 per cent confidence interval (c.i.) \u2212 2\u00b727 to \u2212 0\u00b784) days). On the other hand, it was associated with a significant increase in the incidence of pruritus (odds ratio (OR) 4\u00b78 (95 per cent c.i. 1\u00b73 to 17\u00b70)), urinary retention (OR 4\u00b73 (1\u00b72 to 15\u00b79)) and arterial hypotension (OR 13\u00b75 (4\u00b70 to 57\u00b77)). EA did not influence duration of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite improved analgesia and a decrease in ileus, EA has some adverse effects and does not shorten the duration of hospital stay after colorectal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.5825","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T06:10:40Z","timestamp":1179555040000},"page":"665-673","source":"Crossref","is-referenced-by-count":272,"title":["Meta-analysis of epidural analgesia\n                    <i>versus<\/i>\n                    parenteral opioid analgesia after colorectal surgery"],"prefix":"10.1093","volume":"94","author":[{"given":"E","family":"Marret","sequence":"first","affiliation":[{"name":"Department of Anaesthetics and Intensive Care, Tenon University Hospital, Assistance Publique, H\u00f4pitaux de Paris, University of Pierre and Marie Curie, Faculty of Medicine Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Remy","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics and Intensive Care, Tenon University Hospital, Assistance Publique, H\u00f4pitaux de Paris, University of Pierre and Marie Curie, Faculty of Medicine Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics and Intensive Care, Tenon University Hospital, Assistance Publique, H\u00f4pitaux de Paris, University of Pierre and Marie Curie, Faculty of Medicine Saint Antoine, Paris, 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