{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:26:01Z","timestamp":1783776361781,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T00:00:00Z","timestamp":1200268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008376","name":"K. Albin Johansson Foundation EVO funds, Helsinki University Central Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim was to review a single-institution experience of a prospective treatment protocol for soft tissue sarcoma of the extremity and trunk wall, with particular focus on the smallest surgical margin leading to local control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included 270 patients who had surgery for soft tissue sarcoma at Helsinki University Central Hospital between 1987 and 1997. Resection margins were measured prospectively from tumour specimens. Radiotherapy was administered if the smallest margin measured less than 2\u00b75 cm, irrespective of tumour grade.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With a median follow-up of 6\u00b76 years, the 5-year local control rate was 76\u00b74 per cent. On multivariable analysis, the smallest surgical margin around the sarcoma (after radiotherapy) was prognostic for local control. A margin of at least 2\u00b75 cm was associated with a local recurrence-free rate of 89\u00b72 per cent at 5 years. Tumour size, depth or grade and patient's age had no independent prognostic effect on local control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Surgical margin had independent prognostic value for local control. A surgical margin of 2\u20133 cm provided reasonable local control of soft tissue sarcoma, even without radiotherapy. Radiotherapy is recommended for smaller margins, irrespective of tumour grade.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5906","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T11:49:19Z","timestamp":1187351359000},"page":"237-243","source":"Crossref","is-referenced-by-count":68,"title":["Impact of the smallest surgical margin on local control in soft tissue sarcoma"],"prefix":"10.1093","volume":"95","author":[{"given":"M","family":"Sampo","sequence":"first","affiliation":[{"name":"Department of Pathology, HUSLAB and University of Helsinki , Helsinki,","place":["Finland"]},{"name":"Department of Oncology, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tarkkanen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Helsinki University Central Hospital , Helsinki,","place":["Finland"]},{"name":"Laboratory of Medical Genetics, Helsinki University Central Hospital, and Department of Medical Genetics, Haartman Institute, University of Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Huuhtanen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Tukiainen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"B\u00f6hling","sequence":"additional","affiliation":[{"name":"Department of Pathology, HUSLAB and University of Helsinki , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Blomqvist","sequence":"additional","affiliation":[{"name":"Department of 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