{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:28:29Z","timestamp":1782703709724,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T00:00:00Z","timestamp":1200268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and to determine their relationship to preoperative radiation therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Curatively treated patients participating in the Swedish Rectal Cancer Trial during 1987\u20131990, randomized to preoperative irradiation (454 patients) or surgery alone (454), were matched against the Swedish Hospital Discharge Registry. Hospital records for patients admitted with gastrointestinal diagnoses were reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Irradiated patients had an increased relative risk (RR) of late small bowel obstruction (RR 2\u00b749 (95 per cent confidence interval (c.i.) 1\u00b748 to 4\u00b719)) and abdominal pain (RR 2\u00b709 (95 per cent c.i. 1\u00b703 to 4\u00b724)) compared with patients treated by surgery alone. The risk of late small bowel obstruction requiring surgery was greatly increased (RR 7\u00b742 (95 per cent c.i. 2\u00b723 to 24\u00b766)). Irradiated patients with postoperative anastomotic leakage were at increased risk for late small bowel obstruction (RR 2\u00b799 (95 per cent c.i. 1\u00b707 to 8\u00b731)). The risk of small bowel obstruction was also related to the radiation technique and energy used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Small bowel obstruction is more common in patients with rectal cancer treated with preoperative radiation therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5918","type":"journal-article","created":{"date-parts":[[2007,9,11]],"date-time":"2007-09-11T13:49:28Z","timestamp":1189518568000},"page":"206-213","source":"Crossref","is-referenced-by-count":77,"title":["Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy"],"prefix":"10.1093","volume":"95","author":[{"given":"H","family":"Birgisson","sequence":"first","affiliation":[{"name":"Department of Surgery, Radiology and Clinical Immunology, University Hospital, University of Uppsala , 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