{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:30:24Z","timestamp":1783485024697,"version":"3.55.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T00:00:00Z","timestamp":1203033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Futurum, the Academy of Health Care, J\u00f6nk\u00f6ping County Council, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is lack of consensus in Europe regarding the management of patients with benign goitre. This study evaluated the long-term results of recommending no surgery for clinically and cytologically benign goitre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Some 261 patients (median age 56 years) referred for surgical evaluation for goitre were followed prospectively for a median of 130 months. All hospital and primary care charts were reviewed and living patients interviewed by telephone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During follow-up, 36\u00b74 per cent of patients were re-referred for a new surgical evaluation, mainly because of growth of the goitre and\/or worsening of local symptoms. Fifty-seven (21\u00b78 per cent) of the patients had surgery, and 13 developed thyrotoxicosis. Five patients (1\u00b79 per cent) were diagnosed with thyroid carcinoma, three of whom (all elderly women) died from the disease. Some 95\u00b70 per cent of patients were satisfied with the expectant policy, but 13\u00b71 per cent had been worried about thyroid cancer despite the reassurance of a benign diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with benign goitre can be treated conservatively with good results. However, there is a small risk that aggressive carcinoma will develop and about a quarter of patients may need surgery within 10 years of the decision to wait and see.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.5977","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T13:46:31Z","timestamp":1192023991000},"page":"338-343","source":"Crossref","is-referenced-by-count":6,"title":["Fate of the non-operated, non-toxic goitre in a defined population"],"prefix":"10.1093","volume":"95","author":[{"given":"A","family":"Winbladh","sequence":"first","affiliation":[{"name":"Department of Surgery, Highland Hospital , Eksj\u00f6,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"J\u00e4rhult","sequence":"additional","affiliation":[{"name":"Department of Surgery, Highland Hospital , Eksj\u00f6,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2024093006371522100_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF01659054","article-title":"Endemic goiter and endemic thyroid disorders","volume":"15","author":"Gaitan","year":"1991","journal-title":"World J Surg"},{"key":"2024093006371522100_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/bmj.1.5322.29","article-title":"A survey of thyroid enlargement in two general practices in Great Britain","volume":"1","author":"Kilpatrick","year":"1963","journal-title":"BMJ"},{"key":"2024093006371522100_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1977.tb01340.x","article-title":"The spectrum of thyroid disease in a community: the Whickham Survey","volume":"7","author":"Tunbridge","year":"1977","journal-title":"Clin Endocrinol"},{"key":"2024093006371522100_bib4","first-page":"342","article-title":"Strumapr\u00e4valenz in Deutschland is gr\u00f6sser als bisher angenommen","volume":"90","author":"Hampel","year":"1995","journal-title":"Med Klin"},{"key":"2024093006371522100_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2796.1991.tb00367.x","article-title":"Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking","volume":"229","author":"Petersen","year":"1991","journal-title":"J Intern Med"},{"key":"2024093006371522100_bib6","first-page":"13","article-title":"The prevalence of thyroid disorders in a middle-aged female population, with special reference to the solitary thyroid nodule","volume":"150","author":"Christensen","year":"1984","journal-title":"Acta Chir Scand"},{"key":"2024093006371522100_bib7","first-page":"497","article-title":"Sporadic non-toxic goitre. 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