{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:59:34Z","timestamp":1765666774202},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T00:00:00Z","timestamp":1204588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It is reported that previous colectomy and ileorectal anastomosis (IRA) has no effect on postoperative complications and functional outcomes of secondary proctectomy and ileal pouch\u2013anal anastomosis (IPAA) in patients with familial adenomatous polyposis (FAP). This retrospective study re-examined the question in a single centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Some 185 patients were grouped by either IPAA as the initial prophylactic surgical procedure (primary IPAA) or IPAA preceded by IRA (secondary IPAA). Data on functional outcomes were available for 104, 83 and 56 patients at years 1, 5 and 10 respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 78 patients who had secondary IPAA were older at the time of operation than the 107 who underwent primary IPAA (35\u00b77 versus 29\u00b72 years; P &amp;lt; 0\u00b7001). Six (8 per cent) of the secondary IPAA procedures could not be completed. Otherwise, apart from more wound infections in the secondary IPAA group (9 versus 0\u00b79 per cent in the primary IPAA group; P = 0\u00b7012), there were no significant differences in rates of complications, functional outcomes, desmoid disease or pouch failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Conversion from IRA to IPAA may not be possible in patients with FAP. Where conversion is successful, pouch outcomes are similar but wound infections are more frequent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.6005","type":"journal-article","created":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T12:47:03Z","timestamp":1198846023000},"page":"494-498","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of outcomes of ileal pouch\u2013anal anastomosis for familial adenomatous polyposis with and without previous ileorectal anastomosis"],"prefix":"10.1093","volume":"95","author":[{"given":"A C","family":"von Roon","sequence":"first","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]},{"name":"Department of Biosurgery and Surgical Technology, Imperial College London, St Mary's Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P P","family":"Tekkis","sequence":"additional","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]},{"name":"Department of Biosurgery and Surgical Technology, Imperial College London, St Mary's Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Lovegrove","sequence":"additional","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]},{"name":"Department of Biosurgery and Surgical Technology, Imperial College London, St Mary's Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K F","family":"Neale","sequence":"additional","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K S","family":"Phillips","sequence":"additional","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Clark","sequence":"additional","affiliation":[{"name":"The Polyposis Registry and Department of Surgery, St Mark's Hospital , Harrow, London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2024093006502539300_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1651562","article-title":"Identification of FAP locus genes from chromosome 5q21","volume":"253","author":"Kinzler","year":"1991","journal-title":"Science"},{"key":"2024093006502539300_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","article-title":"Identification and characterization of the familial 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